Alkan, ALPAYSHARIFOV, ResulAkkoyunlu, MUHAMMED EMİNKILICARSLAN, RukiyeToprak, HÜSEYİNAralasmak, AYŞEKART, Levent2019-10-052019-10-052013-11-01Alkan A., SHARIFOV R., Akkoyunlu M. E. , KILICARSLAN R., Toprak H., Aralasmak A., KART L., -MR spectroscopy features of brain in patients with mild and severe obstructive sleep apnea syndrome-, CLINICAL IMAGING, cilt.37, ss.989-992, 2013https://hdl.handle.net/20.500.12645/7299Purpose: We investigated whether there are differences in metabolite ratios of different brain regions between mild and severe obstructive sleep apnea (OSA) patients. Materials and methods: A total of 17 mild OSA and 14 severe OSA patients were enrolled. N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr and NAA/Cho ratios were calculated by using multivoxel magnetic resonance spectroscopy (MRS) (TR: 1500, TE: 135 ms) from hippocampus, putamen, insular cortex, thalamus and temporal white matter. The relationship between the two groups was evaluated with Mann-Whitney U test Results: NAA/Cr ratios obtained from hippocampus was found to be significantly increased in severe OSA patients compared to mild OSA patients (P=.004). Cho/Cr ratios obtained from hippocampus and putamen in severe OSA patients were significantly increased when compared to mild OSA patients (P=.003 and P=.004, respectively). In addition, NAA/Cho ratios of putamen were significantly decreased in severe OSA patients when compared to mild OSA (P=.032). Conclusion: MRS identified hypoxia-related metabolite and microstructural changes in hippocampus and putamen. The metabolite changes of increase in NAA/Cr and Cho/Cr ratios and decrease in NAA/Cho ratio were more pronounced with increasing severity of OSA syndrome. (C) 2013 Elsevier Inc. All rights reserved.enArticle23993754