Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.

GÜZEL-AKDEMIR, ÖAkdemir, ATİLLAKARALı, NSUPURAN, CT2019-10-052019-10-052015-06-21GÜZEL-AKDEMIR Ö., Akdemir A., KARALı N., SUPURAN C., -Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.-, Organic & biomolecular chemistry, cilt.13, ss.6493-9, 2015https://hdl.handle.net/20.500.12645/6180https://pubs.rsc.org/en/content/articlelanding/2015/OB/C5OB00688K#!divAbstractA series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII – recently validated antitumor drug targets, being much less effective as inhibitors of the off-target cytosolic isoforms CA I and II.entumorDiscovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.ArticleWOS:0003558596000118493068120810.1039/c5ob00688k