Bahadori, FatemehDag, AydanDurmaz, HakanCakir, NeseONYUKSEL, HayatTunca, ÜmitTopcu, GulactiHızal, Gürkan2020-10-292020-10-292014-01-01Bahadori F., Dag A., Durmaz H., Cakir N., ONYUKSEL H., Tunca Ü., Topcu G., Hızal G., -Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine-, POLYMERS, cilt.6, ss.214-242, 2014http://hdl.handle.net/20.500.12645/25554https://www.mdpi.com/journal/polymersTwo amphiphilic block copolymers using hydrophobic poly(e-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B)(4) type star polymer [(PCL-b-PEG)(4)] and the other one is a Y-shaped PEG-(PCL)(2). A star-shaped polymer (PCL-b-PEG)(4) was prepared by ring-opening polymerization (ROP) of epsilon-caprolactone continued by click reaction of (PCL-azide)(4) and PEG-alkyne. The synthesis of Y-shaped PEG-(PCL)(2) block copolymer was carried out via Diels-Alder click reaction of a furan protected maleimide end-functionalized PEG (PEG-MI) with an anthracene end-functionalized PCL following the ROP of epsilon-caprolactone. The characterization of micelles is carried out using both materials in aqueous media as drug delivery vehicles, which showed satisfying results and enhanced the cytotoxic effect of the anti-cancer drug vinorelbine (VLB). However, micelles consisted of Y-shaped unimers were found to be more convenient for delivery of hydrophobic drugs such as VLB because they formed in lower concentration, carrying a higher amount of drugs and owing a monomodal distribution. We concluded that the free tails of hydrophobic chains in Y-shaped block copolymer facilitate the assembly of amphiphilic material in water to form micelles.polymeric drug delivery systemsArticleWOS:0003360918000138489404200210.3390/polym6010214