Esentürk-Güzel I.ALĞIN YAPAR E.Cavalu S.ŞEKER İ. T.İNAL E.KARTAL M.Koç R. Ç.Öztürk R. Y.Göksu F.Bölek S.et al.2024-03-272024-03-272024-01-01Esentürk-Güzel I., ALĞIN YAPAR E., Cavalu S., ŞEKER İ. T., İNAL E., KARTAL M., Koç R. Ç., Öztürk R. Y., Göksu F., Bölek S., et al., "DESIGN AND EVALUATION OF PROPOLIS-HPC/PVP ELECTROSPUN NANOFIBERS FOR POSSIBLE CUTANEOUS APPLICATIONS", Farmacia, cilt.72, sa.1, ss.200-213, 20240014-8237https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85186181572&origin=inwardhttps://hdl.handle.net/20.500.12645/39175The aim of the study was to prepare propolis loaded hydroxypropyl cellulose and polyvinyl pyrrolidone (HPC/PVP) nanofibers, suitable for cutaneous applications. LC-HRMS analyses were applied for the identification and quantification of the bio-compounds in the propolis extract. Electrospinning was applied in order to prepare propolis HPC/PVP nanofibers with increasing concentration of propolis 10%, 20% and 30 % (v/v) and subsequently characterized in terms of morphology, wettability, thermal degradation and biological properties. SEM images showed homogenous features of the nanofibers and average diameter between 197.2-268.4 nm, high antioxidant activity, very good biocompatibility and no cytotoxicity. Particularly, with the highest propolis concentration, 30-PE/HPC/PVP nanofiber formulation is a promising alternative to conventional treatments for cutaneous applications.info:eu-repo/semantics/openAccessEczacılıkTemel Eczacılık BilimleriYaşam BilimleriSağlık BilimleriTemel BilimlerPharmacology and TherapeuticsBasic Pharmaceutics SciencesLife SciencesHealth SciencesNatural SciencesYaşam Bilimleri (LIFE)Farmakoloji ve ToksikolojiFARMAKOLOJİ VE ECZACILIKLife Sciences (LIFE)PHARMACOLOGY & TOXICOLOGYPHARMACOLOGY & PHARMACYGenel Farmakoloji, Toksikoloji ve EczacılıkGeneral Pharmacology, Toxicology and Pharmaceuticsbiocompatibilityelectrospinninghdroxypropylcellulosenanofiberspolyvinyl pyrollidonepropolisarticle8518618157210.31925/farmacia.2024.1.22200213721