Sen, AlaattinAyar, BuketYilmaz, AnilAcar, Ozden OzgunTurgut, Gurbet CelikTOPÇU, GÜLAÇTI2020-01-152020-01-152019-01-01Sen A., Ayar B., Yilmaz A., Acar O. O. , Turgut G. C. , TOPÇU G., -Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption-, TURKISH JOURNAL OF CHEMISTRY, cilt.43, ss.1350-1372, 2019https://openaccess.bezmialem.edu.tr/handle/20.500.12645/13219Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption (a-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses:enArticleWOS:0004891115000108507380011510.3906/kim-1904-57DOI: https://doi.org/10.3906/kim-1904-57DOI: https://doi.org/10.3906/kim-1904-57trdizin