Seker, MESUTAYDIN, DincerBilici, AhmetYAVUZER, DilekOZGUN, Melin G.OZCELIK, MelikeAYDIN, OzhanALIUSTAOGLU, Mehmet2019-10-052019-10-052017-04-01Seker M., AYDIN D., Bilici A., YAVUZER D., OZGUN M. G. , OZCELIK M., AYDIN O., ALIUSTAOGLU M., -Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy-, ONCOLOGY RESEARCH AND TREATMENT, cilt.40, ss.185-190, 2017https://hdl.handle.net/20.500.12645/2549Background: Upregulation of caveolin-1 (Cav-1) expression is correlated with histopathological grade and poor prognosis in several human cancers. However, in gastric cancer, its clinical utility as a useful prognostic molecular marker remains unclear. Methods: The prognostic importance of Cav-1 expression was retrospectively analyzed by immunohistochemistry in 148 patients with gastric cancer who had undergone radical gastrectomy. Results: Cav-1 expression was positive in 23 (15.5%) patients and negative in 125 (84.5%) patients. Tumor location, tumor grade, lymph node involvement, pT stage, pTNM stage, and the presence of recurrence were found to be significantly associated with Cav-1 expression. The median disease-free survival (DFS) of patients with negative Cav-1 expression was significantly better than that of patients with positive Cav-1 expression (not reached vs. 10.2 months, p < 0.001). Moreover, patients with positive Cav-1 expression had a worse median overall survival (OS) compared to patients with negative Cav-1 expression (14.2 vs. 40.3 months, p = 0.004). In the multivariate analysis, Cav-1 expression (positive vs. negative) was an independent prognostic factor for DFS (p < 0.001, hazard ratio (HR) 2.58) and OS (p = 0.031, HR 1.87), as was lymph node metastasis. Conclusion: Our results suggest that positive Cav-1 expression is associated with progression and poor prognosis in gastric cancer patients after radical gastrectomy. Targeting Cav-1 would be a potential option for future gastric cancer treatment. (C) 2017 S. Karger GmbH, FreiburgenArticle