Publication:
Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.

Loading...
Thumbnail Image
Date
2014-01-01
Authors
OZGURHAN, G
DEMIR, AD
Uzuner, SELÇUK
NURSOY, MUSTAFA ATİLLA
TURKMEN, S
KACAN, A
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
Background. The two most frequent types of microcytic anemia are beta thalassemia trait (𝛽-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and 𝛽-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1–16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7–11.4 g/dL. None of the subjects had a combined case of IDA and 𝛽-TT. All children with IDA received oral iron for 16 weeks, and HbA2 screening was performed after iron therapy. The patient groups were evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lal, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden’s index (81%) for detecting 𝛽-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion.The Mentzer index provided the highest reliabilities for differentiating 𝛽-TT from IDA.
Description
Keywords
Citation
VEHAPOGLU A., OZGURHAN G., DEMIR A., Uzuner S., NURSOY M. A. , TURKMEN S., KACAN A., -Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.-, Anemia, cilt.2014, ss.576738, 2014
Page Views

2

File Downloads

22

Sustainable Development Goals