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Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations

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Date
2013-01-01
Author
Onal, Armagan
Bahadori, FATEMEH
Tekkeli, Serife Evrim Kepekci
Advisor
Type
Article
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Abstract
This study presents three simple, rapid, and accurate spectrophotometric methods for the determination of Rasagiline (RSG) in pharmaceutical preparations. The determination procedures depend on the reaction of RSG with chloranilic acid for method A, tetrachloro-1,4-benzoquinone for method B, and 7,7,8,8-tetracyanoquinodimethane for method C. The colored products were quantitated spectrophotometrically at 524, 535, and 843 nm for methods A, B, and C, respectively. Different variables affecting the reaction were optimized. Linearity ranges of the methods with good correlation coefficients (0.9988-0.9996) were observed as 25-300 mu g mL(-1), 25-350 mu g mL(-1), and 50-500 mu g mL(-1) for methods A, B, and C, respectively. The formation of products takes place through different mechanisms. The sites of interaction were confirmed by elemental analysis using IR and H-1-NMR spectroscopy. The validation of the methods was carried out in terms of specificity, linearity, accuracy, precision, robustness, limit of detection, and limit of quantitation. No interference was observed from concomitants usually present in dosage forms. The methods were applied successfully to the determination of RSG in pharmaceutical preparations.
Subject
Tekkeli S. E. K. , Onal A., Bahadori F., -Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations-, JOURNAL OF SPECTROSCOPY, 2013
URI
https://hdl.handle.net/20.500.12645/7834
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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS