Publication: Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis
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Date
2017-09-01
Authors
Okyaltirik, FATMANUR
Rezvani, AYLİN
Turan, Saime
Uysal, Omer
YAKAR, Fatih
SÖZGEN, Hatice
Ozkan, Nazli Ezgi
Akkoyunlu, Muhammet Emin
Bayram, MEHMET
Ozcelik, Hatice Kutbay
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Abstract
Background and AimsAnkylosing spondylitis (AS) is a multisystem disorder with ocular, pulmonary, and cardiovascular involvement. The incidence of pulmonary involvement varies from 1 to 52%. Abnormal T-cell function-derived immune responses are involved in AS pathogenesis. Numerous genes such as CTLA4 and CD28 control T-cell functions. In this study, we aimed to address the relationship between CTLA4 and CD28 polymorphisms and lung involvement in Turkish patients with AS.
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Okyaltirik F., Rezvani A., Turan S., Uysal O., YAKAR F., SÖZGEN H., Ozkan N. E. , Akkoyunlu M. E. , Bayram M., Ozcelik H. K. , et al., -Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis-, CLINICAL RESPIRATORY JOURNAL, cilt.11, ss.593-601, 2017