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dc.contributor.authorDag, AYDAN
dc.contributor.authorCALLARI, Manuela
dc.contributor.authorLu, Hongxu
dc.contributor.authorSTENZEL, Martina H.
dc.date.accessioned2019-10-05T14:55:31Z
dc.date.available2019-10-05T14:55:31Z
dc.date.issued2016-01-01
dc.identifier10.1007/s10620-010-1399-7
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5076
dc.description.abstractThe therapeutic potency of platinum-based anticancer drugs can be substantially improved through the use of polymeric nano-carrier systems to target cancer cells efficiently. We synthesized a series of glyco-block copolymers with three different sugars able to self-assemble into nanoparticles when conjugated with 1,2-diamino-cyclopentane platinum(II) (DACP-Pt). The polymers are based on (2-(D-glucosyloxy) ethyl methacrylate (glucose; GlcMA), 2-(D-galactosyloxy) ethyl methacrylate (galactose; GalMA), 1-O-methacryloyl-beta-D-fructopyranose (fructose; FrucMA1), and 3-Omethacryloyl-beta-D-fructopyranose (fructose; FrucMA3)). They are all readily taken up intracellularly by the breast cancer cell lines MCF-7 and MDA-MB-231 and the ovarian cancer cell line A2780. All cell lines expressed a high preference for the fructose coated nanoparticles. The nanocarriers were themselves nontoxic, but exhibited high cytotoxicity and increased efficacy when conjugated with the DACP-Pt drug.
dc.language.isoen
dc.subjectDag A., CALLARI M., Lu H., STENZEL M. H. , -Modulating the cellular uptake of platinum drugs with glycopolymers-, POLYMER CHEMISTRY, cilt.7, ss.1031-1036, 2016
dc.titleModulating the cellular uptake of platinum drugs with glycopolymers
dc.typeArticle
local.avesis.response4946
local.article.journalnameDIGESTIVE DISEASES AND SCIENCES
dc.identifier.wosWOS:000368896300003
dc.identifier.scopus84955617269
dc.identifier.doi10.1039/c5py01579k
local.publication.isinternational1


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