Publication: Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor
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Date
2016-10-13
Authors
Kılıç, Elif
Ozer, Omer Faruk
Erek, Aybala Toprak
ERMAN, HAYRİYE
Torun, EMEL
AYHAN, Siddika Kesgin
Caglar, HİFA GÜLRU
Selek, Sahbettin
Kocyigit, ABDÜRRAHİM
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Abstract
Background: Childhood obesity characterized by excessive fat in the body is one of the most serious health problems worldwide due to the social, medical, and physiological complications. Obesity and associated diseases are triggering factors for oxidative stress and inflammation. The aim of this study was to explore the possible association
between childhood obesity and inflammatory and oxidative status.
Material/Methods: Thirty-seven obese children and 37 healthy controls selected from among children admitted to BLIND University
Paediatrics Department were included in the study. Anthropometric measurements were performed using standard methods. Glucose, lipid parameters, CRP, insulin, total oxidant status (TOS), total anti-oxidant status (TAS)
levels, and total thiol levels (TTL) were measured in serum. HOMA index (HOMA-IR) were calculated. The differences between the groups were evaluated statistically using the Mann-Whitney U test.
Results: Body mass index was significantly higher in the obese group (median: 28.31(p<0.001). Glucose metabolism,
insulin, and HOMA-IR levels were significantly higher in the obese group (both p<0.001). Total cholesterol, HDL
cholesterol, LDL cholesterol, and triglyceride levels were significantly higher in the obese group (p<0.001). TAS
(med: 2.5 µmol Trolox eq/L (1.7–3.3)) and TOS (med: 49.1 µmol H2
O2
eq/L (34.5–78.8)) levels and TTL (med:
0.22 mmol/L (0.16–0.26)) were significantly higher in the obese group (p=0.001). CRP levels showed positive
correlation with TOS and negative correlation with TTL levels (p=0.005, r=0.473; p=0.01, r=–0.417; respectively). TTL levels exhibited negative correlation with TOS levels (p=0.03, r=–0.347).
Conclusions: In conclusion, obese children were exposed to more oxidative burden than children with normal weight. Increased
systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. Widely focussed studies are required on the use of oxidative parameters as early prognostic parameters in detection of obesity-related complications
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Citation
Kılıç E., Ozer O. F. , Erek A. T. , ERMAN H., Torun E., AYHAN S. K. , Caglar H. G. , Selek S., Kocyigit A., -Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor-, MEDICAL SCIENCE MONITOR, cilt.22, ss.3673-3679, 2016