Publication:
The efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model

Loading...
Thumbnail Image
Date
2014-03-01
Authors
Sonmez, ERTAN
ÇAVUŞ, Umut Yucel
CİVELEK, Cemil
DUR, Ali
KARAYEL, Eda
Gulen, BEDİA
Uysal, Omer
İPEK, Gokturk
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
Background: Bleeding is a major problem in warfarin pretreated patients who need emergency surgical procedures. APH is a hemostatic agent with ultra-hydrophilic and particulate properties. This study aimed to evaluate the in vivo hemostatic effect of APH in rats pretreated with warfarin. Methods: Forty-eight Wistar rats were divided into two main groups: one group was pretreated with warfarin and the other group was not. These two groups were further divided into three subgroups according to the administration of APH, wheat meal, or saline, for a total of six subgroups. Standard full thickness tissue defects were performed on the backs of the rats. Saline, wheat meal, or APH were administered to the bleeding defect site in both main groups. Hemostasis time and amount of bleeding were calculated. Results: The bleeding time in rats administered APH was significantly shorter than those administered wheat meal and saline. Consequently, the amount of bleeding was significantly less in the APH groups than in the control groups. Conclusion: APH has an effective hemostatic property in rats pretreated or non-pretreated with anticoagulants. Hemostatic agents can be useful for incidences of external bleedings, which are increasing because of anticoagulation.
Description
Keywords
Citation
Sonmez E., ÇAVUŞ U. Y. , CİVELEK C., DUR A., KARAYEL E., Gulen B., Uysal O., İPEK G., -The efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model-, ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.20, ss.79-85, 2014
Page Views

0

File Downloads

2

Sustainable Development Goals