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dc.contributor.authorElibol, BİRSEN
dc.contributor.authorKILIC, U
dc.date.accessioned2019-10-05T13:48:59Z
dc.date.available2019-10-05T13:48:59Z
dc.date.issued2018-10-15
dc.identifier10.1080/00207450390232300
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3074
dc.description.abstractSIRT1 protein, a member of Silent Information Regulator 2 (Sir2) protein family, have gained considerable attention as epigenetic regulators for a great area in the human physiology. Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, cardiovascular diseases, cancer and neurodegeneration. Here, we provide an overview of the association of the increasing level of SIRT1 protein for regulating some disease related conditions such as obesity, cardiovascular diseases and neurodegeneration. This review also provides a detailed molecular understanding of the interaction of the some basic molecules with increasing SIRT1 levels rather than reduction of the SIRT1 expression. In this context, the current approaches to enhancing the expression of SIRT1 points the importance of epigenetics in several age-related diseases to provide a healthy aging by developing novel therapies which can prevent or damp the progression of some diseases.en
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectElibol B., KILIC U., -High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.-, Frontiers in endocrinology, cilt.9, ss.614, 2018
dc.titleHigh Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
dc.typeArticle
local.avesis.response2944
local.article.journalnameINTERNATIONAL JOURNAL OF NEUROSCIENCE
dc.identifier.wosWOS:000447273000001
dc.identifier.scopus85055294681
dc.identifier.doi10.3389/fendo.2018.00614
dc.identifier.pubmed30374331
local.publication.isinternational1


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