Publication: Coagulation parameters in inflammatory bowel disease
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Date
2014-01-01
Authors
Authors
DOLAPCIOGLU, Can
SOYLU, Aliye
KENDIR, Tulin
Ince, ALİ TÜZÜN
DOLAPCIOGLU, Hatice
Purisa, Sevim
BOLUKBAS, Cengiz
SOKMEN, Haci Mehmet
DALAY, Remzi
OVUNC, Oya
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Abstract
Thromboembolic events represent a major cause of morbidity and mortality in patients with inflammatory
bowel disease and they may occur both at the gastrointestinal tract and at extraintestinal sites. This study aimed to
examine the alterations in coagulation parameters involved at different steps of hemostasis in patients with Crohn’s
disease and ulcerative colitis, in comparison with healthy individuals. Fifty-one patients with inflammatory bowel disease and 26 healthy controls were included in this study. Plasma levels of PT, APTT, AT III, plasminogen, fibrinogen,
D-dimer, factor V, factor VIII, protein C, protein S, and APCR were measured and factor V Leiden mutation was examined in both patients and controls. Two patients with ulcerative colitis had a history of previous thromboembolic
event. Inflammatory bowel disease was associated with significantly higher levels of fibrinogen, PT, factor V, factor
VIII, plasminogen and thrombocyte. Protein S, fibrinogen, plasminogen and thrombocyte levels were associated with
disease activity, depending on the type of the disease (Crohn’s disease or ulcerative colitis). The coagulation abnormalities detected in this study seems to be a secondary phenomena resulting from the disease process, which is
more likely to be associated with a multitude of factors rather than a single abnormality
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Citation
DOLAPCIOGLU C., SOYLU A., KENDIR T., Ince A. T. , DOLAPCIOGLU H., Purisa S., BOLUKBAS C., SOKMEN H. M. , DALAY R., OVUNC O., -Coagulation parameters in inflammatory bowel disease-, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.7, ss.1442-1448, 2014