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Cheminformatics-Based Drug Design Approach for Identification of Inhibitors Targeting the Characteristic Residues of MMP-13 Hemopexin Domain

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Date
2010-08-01T00:00:00Z
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Kothapalli, Roopa
KHAN, MOHAMMAD ASİF
Basappa, Basappa
Gopalsamy, Anupriya
Chong, Yap Seng
Annamalai, Loganath
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Abstract
Background: MMP-13, a zinc dependent protease which catalyses the cleavage of type II collagen, is expressed in osteoarthritis (OA) and rheumatoid arthritis (RA) patients, but not in normal adult tissues. Therefore, the protease has been intensively studied as a target for the inhibition of progression of OA and RA. Recent reports suggest that selective inhibition of MMP-13 may be achieved by targeting the hemopexin (Hpx) domain of the protease, which is critical for substrate specificity. In this study, we applied a cheminformatics-based drug design approach for the identification and characterization of inhibitors targeting the amino acid residues characteristic to Hpx domain of MMP-13; these inhibitors may potentially be employed in the treatment of OA and RA.
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Kothapalli R., KHAN M. A. , Basappa B., Gopalsamy A., Chong Y. S. , Annamalai L., -Cheminformatics-Based Drug Design Approach for Identification of Inhibitors Targeting the Characteristic Residues of MMP-13 Hemopexin Domain-, PLOS ONE, cilt.5, sa.8, 2010
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