Publication: LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)
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Date
2021-05-01T00:00:00Z
Authors
Authors
Kızıltaş, Hatice
Bingol, Zeynebe
GÖREN, AHMET CEYHAN
Kose, Leyla Polat
DURMAZ, LOKMAN
Topal, Fevzi
Alwasel, Saleh H.
GÜLÇİN, İlhami
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Abstract
Kınkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine
against some diseases. As far as we know, the data are not available on the biological activities
and chemical composition of this medicinal plant. In this study, the phytochemical composition;
some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of
this plant were assessed. In order to evaluate the antioxidant activity of evaporated ethanolic
extract (EEFS) and lyophilized water extract (WEFS) of kınkor (Ferulago stellata), some putative
antioxidant methods such as DPPH· scavenging activity, ABTS•+
scavenging activity, ferric ions
(Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+)-binding
activities were separately performed. Furthermore, ascorbic acid, BHT, and α-tocopherol were used
as the standard compounds. Additionally, the main phenolic compounds that are responsible for
antioxidant abilities of ethanol and water extracts of kınkor (Ferulago stellata) were determined by
liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol and water extracts
of kınkor (Ferulago stellata) demonstrated effective antioxidant abilities when compared to standards.
Moreover, ethanol extract of kınkor (Ferulago stellata) demonstrated IC50 values of 1.772 µg/mL
against acetylcholinesterase (AChE), 33.56 ± 2.96 µg/mL against α-glycosidase, and 0.639 µg/mL
against α-amylase enzyme respectively.
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Keywords
Ferulago stellata, kınkor, acetylcholinesterase, antioxidant activity, α-glycosidase, α-amylase, polyphenol content, LC-HRMS