Publication:
D-dimer Level is an Early Marker of Ischaemia/ reperfusion Injury After Coronary Artery Bypass Surgery

No Thumbnail Available
Date
2019-12-01T00:00:00Z
Authors
Çakalağaoğlu, Kamil
Keski̇n, Gökhan
Altaş, Özge
Selçuk, Emre
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
Introduction: Myocardial Ischaemia-Reperfusion (I-R) injury produces a spectrum of clinical cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation and amplification of several systemic and local proinflammatory pathways. The process of restoring blood flow to the ischaemic myocardium can induce injury and paradoxically reduce the beneficial effects of myocardial reperfusion. The objective of this study was to determine the correlation between cardiac markers such as the Mb fraction of the creatine kinase (CK-MB), troponin I (cTnI) and D-dimer levels as a marker of myocardial injury secondary to I-R injury after coronary artery bypass surgery. Patients and Methods: Herein, a prospective study was designed that included 50 consecutive coronary artery bypass grafting (CABG) patients. Pre and postoperative blood samples were taken due to study protocol and such markers as Mb fraction of the creatine kinase (CK-MB), troponin I (cTnI) and D-dimer were measured. Results: All three markers were significantly elevated in postoperative blood samples. The D-dimer level reached its peak at the first and another peak at 12th hour postoperatively. However, the peak serum values of CK-MB and cTnI occurred at 6th and 12th hour, respectively. Conclusion: We demonstrated that D-dimer levels as a marker of generated thrombin during reperfusion correlated with other well-known biochemical markers of myocardial damage in the postoperative period. In other words, D-dimer levels may stand as a marker of I-R-induced myocardial damage.
Description
Keywords
Citation
Erdem H., Çakalağaoğlu K., Selçuk E., Keski̇n G., Altaş Ö., Köksal C., -D-dimer Level is an Early Marker of Ischaemia/ reperfusion Injury After Coronary Artery Bypass Surgery-, Koşuyolu Heart Journal, cilt.22, sa.3, ss.198-204, 2019
Page Views

3

File Downloads

0

Sustainable Development Goals