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dc.contributor.authorTurker, Yasin; Aslantas, Yusuf; Turker, Yasemin; Akkaya, Mehmet; Ucgun, Taner; Erkan, Melih Engin
dc.description.abstractTrypanosoma cruzi, the causative agent of Chagas disease, encodes for an alpha-carbonic anhydrase (CA, EC possessing high catalytic activity (TcCA) which was recently characterized (Pan et al. J. Med. Chem. 2013, 56, 1761-1771). A new class of sulfonamides possessing low nanomolar/subnanomolar TcCA inhibitory activity is described here. Aromatic/heterocydic sulfonamides incorporating halogeno/methoxyphenacetamido tails inhibited TcCA with K(I)s in the range of 0.5-12.5 nM, being less effective against the human off-target isoforms hCA I and II. A homology model of TcCA helped us to rationalize the excellent inhibition profile of these compounds against the protozoan enzyme, a putative new antitrypanosoma drug target. These compounds were ineffective antitrypanosomal agents in vivo due to penetrability problems of these highly polar molecules that possess sulfonamide moieties.
dc.subjectMitral regurgitation; NYHA class; Pro-adrenomedullin
dc.titleA novel indicator for assessment of mitral regurgitation severity: Pro-adrenomedullin

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