Publication:
Deciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma

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Date
2021-02-01T00:00:00Z
Authors
KHAN, IMRAN
Baig, Mohammad Hassan
Mahfooz, Sadaf
Rahim, Moniba
KARAÇAM, BÜŞRA
ELBASAN, Elif Burçe
Ulasov, Ilya
Dong, Jae-June
HATİBOĞLU, MUSTAFA AZİZ
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Research Projects
Sustainable Development Goals
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Abstract
Autophagy is a process essential for cellular energy consumption, survival, and defense mechanisms. The role of autophagy in several types of human cancers has been explicitly explained; however, the underlying molecular mechanism of autophagy in glioblastoma remains ambiguous. Autophagy is thought to be a -double-edged sword-, and its effect on tumorigenesis varies with cell type. On the other hand, autophagy may play a significant role in the resistance mechanisms against various therapies. Therefore, it is of the utmost importance to gain insight into the molecular mechanisms deriving the autophagy-mediated therapeutic resistance and designing improved treatment strategies for glioblastoma. In this review, we discuss autophagy mechanisms, specifically its pro-survival and growth-suppressing mechanisms in glioblastomas. In addition, we try to shed some light on the autophagy-mediated activation of the cellular mechanisms supporting radioresistance and chemoresistance in glioblastoma. This review also highlights autophagy’s involvement in glioma stem cell behavior, underlining its role as a potential molecular target for therapeutic interventions.
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Keywords
autophagy , chemoresistance , glioblastoma , glioma stem cells , molecular targets , radioresistance
Citation
KHAN I., Baig M. H. , Mahfooz S., Rahim M., KARAÇAM B., ELBASAN E. B. , Ulasov I., Dong J., HATİBOĞLU M. A. , -Deciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma-, International Journal of Molecular Sciences, cilt.22, ss.1-26, 2021