Publication:
Radiological and Stereological Evaluation of the Effect of Rifampin on Bone Healing in Critical-Size Defects

No Thumbnail Available
Date
2016-09-01T00:00:00Z
Authors
Durmuslar, Mustafa Cenk
Balli, UMUT
Turer, Akif
Onger, Mehmet E.
ÇELİK, HAKAN HAMDİ
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
Objectives:This study aimed to investigate the effect of rifampin with autogenous bone on bone regeneration in critical-size defects in the calvaria of rats.Materials and Methods:In total, 40 rats were divided into 4 groups and a 5-mm diameter of calvarial defect was made in each rat-s calvarium. Control group (C), bone defects were irrigated with sterile saline; rifampin group (R), bone defects were irrigated with rifampin. In the autogenous graft group (Ag), the autogenous graft was contaminated with saliva, and the defects were filled with an autogenous graft. In the autogenous graft + rifampin group (Ag+R), the autogenous graft was contaminated with saliva and was decontaminated with rifampin, and the defects were filled with the autogenous graft. The animals were killed at 4weeks. Bone formation was assessed by micro-computed tomography scanning and stereological analyses.Results:The mean new bone volume was the greatest in the Ag/rifampin group (1.730.17), followed by the Ag group (1.50 +/- 0.05) (statistically significant difference at P0.05).Conclusion:This study, despite its limitations, showed that rifampin with autogenous bone increased bone regeneration in rats with critical-size defects.
Description
Keywords
Citation
Durmuslar M. C. , Balli U., Turer A., Onger M. E. , ÇELİK H. H. , -Radiological and Stereological Evaluation of the Effect of Rifampin on Bone Healing in Critical-Size Defects-, JOURNAL OF CRANIOFACIAL SURGERY, cilt.27, ss.1481-1485, 2016
Collections
Page Views

0

File Downloads

0

Sustainable Development Goals