Publication: Histological Evaluation of the Effect of Concentrated Growth Factor on Bone Healing
No Thumbnail Available
Date
2016-09-01T00:00:00Z
Authors
Authors
Durmuslar, Mustafa Cenk
Balli, UMUT
Dede, Figen Ongoz
Misir, Ahmet Ferhat
BARIŞ, EMRE
KÜRKÇÜ, MEHMET
Kahraman, Sevil Altindag
Journal Title
Journal ISSN
Volume Title
Publisher
Metrics
Abstract
Objectives:The aim of this study was to evaluate the effects of concentrated growth factors (CGF) on the healing of peri-implant bone defects in an animal model.Study Design:Twenty 4-month-old New Zealand White rabbits, each with an average weight of 3.5kg, were used in this blinded, prospective, experimental study. Two implants were placed and 2 peri-impant defects were prepared in each rabbit tibia. Bone defects were created monocortically in the tibia of each rabbit using a trephine burr with a diameter of 8mm. The implants were installed in each hole. The rabbits were divided into 4 groups: in group E, the defect was left empty; in group CGF, the defects were filled only with CGF; in group AB, the defects were filled with autogenous bone; and in group AB+CGF, the defects were filled with autogenous bone and CGF. The animals were euthanized at week 8 postimplantation. All implants from the 20 animals were fixed in 10% formalin and evaluated histomorphometrically.Results:The mean defect area was highest in group E and lowest in group CGF+AB (P<0.05). The area of the defect differed significantly between groups AB and CGF+AB (P<0.05), but not between groups CGF and E. Implant-to-bone contact was lowest in group E. In the defect areas of groups CGF, AB and CGF+AB, a small amount of new bone formed around the implant.Conclusions:In this animal model of a peri-implant bone defect, restoration was achieved using a combination of autogenous bone and CGF. Further studies are needed to determine the behavior of CGF when used in the repair of bone defects in humans.
Description
Keywords
Citation
Durmuslar M. C. , Balli U., Dede F. O. , Misir A. F. , BARIŞ E., KÜRKÇÜ M., Kahraman S. A. , -Histological Evaluation of the Effect of Concentrated Growth Factor on Bone Healing-, JOURNAL OF CRANIOFACIAL SURGERY, cilt.27, ss.1494-1497, 2016