Publication: The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases
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Date
2013-04-01T00:00:00Z
Authors
Authors
Kiran, Tuğçe
Demirkesen, Cuyan
Eker, Candan
Kumusoglu, Hakki
Tuzuner, Nukhet
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Abstract
Current laboratory technics, clinicopathologic findings cannot always reliably distinguish primary cutaneous CD30(+) lymphoproliferative disorders (LPD), such as lymphomatoid papulosis (LyP), primary cutaneous CD30(+) anaplastic large cell lymphoma (PCALCL), transformed mycosis fungoides (T-MF) and systemic ALK(−) anaplastic large cell lymphoma (ALCL) with skin involvement. We investigated the presence of IRF4 translocation with break apart DNA-FISH method of these entities according to the recent studies of Feldman et al.
In our study group with 53 cases, the detection of IRF4 translocation had a specificity and positive predictive value for PCALCL of 100%. In contrast MUM1/IRF4 protein expression was distributed widely without any predictive value.
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Keywords
ALCL, IRF4 translocation
Citation
Kiran T., Demirkesen C., Eker C., Kumusoglu H., Tuzuner N., -The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases-, LEUKEMIA RESEARCH, cilt.37, ss.396-400, 2013