Publication: A class of sulfonamides as carbonic anhydrase I and II inhibitors
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Date
2016-12-01T00:00:00Z
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GOKCEN, Taner
GÜLÇİN, İlhami
OZTURK, Turan
Goren, AHMET CEYHAN
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Abstract
Four groups of novel sulfonamide derivatives: (i) acetoxybenzamide, (ii) triacetoxybenzamide, (iii) hydroxybenzamide and (iv) trihydroxybenzamide, all having thiazole, pyrimidine, pyridine, isoxazole and thiadiazole moieties were prepared and their inhibitory effects were studied on two metalloenzymes, i.e. carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity chromatography. These enzymes are present in almost all living organisms to catalyse the synthesis of bicarbonate ion (HCO3-) from carbon dioxide and water. The sulfonamide derivatives were found to be active against hCA I and II in the range of 2.62-136.54 and 5.74-210.58nM, respectively.
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GOKCEN T., GÜLÇİN İ., OZTURK T., Goren A. C. , -A class of sulfonamides as carbonic anhydrase I and II inhibitors-, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.31, ss.180-188, 2016