Publication: The cytokine response in THP-1 (monocyte) and HL-60 (neutrophil-differentiated) cells infected with different genotypes of Helicobacter pylori strains
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2015-07-01T00:00:00Z
Authors
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Caliskan, Reyhan
Yazgan, Ayca Sayi
Tokman, Hrisi Bahar
Sofyali, Emre
Erzin, Yusuf Ziya
Akgul, Ozer
Kurt, Aykut
Kalayci, Fatma
Ziver, Tevhide
Yuksel, Pelin
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Abstract
Background/Aims: Helicobacter pylori (H. pylori) is a microaerophilic bacterium related with peptic ulcer and gastric cancer. Its virulence factors include cytotoxin-associated gene A (CagA) and vacuolating cytotoxin gene A (VacA) proteins. Cytokine release inducted by H. pylori colonization has an important role in pathogenesis of H. pylori. The severity of gastric pathologies depends on the H. pylori genotypes found in different geographical regions. We aimed to determine the relationship between different H. pylori genotypes and their effects on the cytokine release levels.
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Caliskan R., Yazgan A. S. , Tokman H. B. , Sofyali E., Erzin Y. Z. , Akgul O., Kurt A., Kalayci F., Ziver T., Yuksel P., et al., -The cytokine response in THP-1 (monocyte) and HL-60 (neutrophil-differentiated) cells infected with different genotypes of Helicobacter pylori strains-, TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.26, ss.297-303, 2015