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Cuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment

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2013-10-01T00:00:00Z
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Basoglu, HARUN
Boylu, N. T.
KOSE, H.
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Abstract
OBJECTIVES: Multiple Sclerosis (MS) is a disease that affects the Central Nervous System by destructing myelin shield and also can affects the peripheral nervous system. Demyelination is acquired characteristics disease and appears with the degeneration of myelin which protects the axons. Cuprizone (CPZ) model is a toxic demyelination model. The purpose of this study was to develop an MS model by cuprizone exposure toWistar rats.
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Basoglu H., Boylu N. T. , KOSE H., -Cuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment-, EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.17, ss.2711-2717, 2013
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http://hdl.handle.net/20.500.12645/25341
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