Publication:
Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NF kappa B and Akt/mTOR Signaling Pathways

No Thumbnail Available
Date
2012-01-01T00:00:00Z
Authors
Authors
Sahin, K.
Tuzcu, M.
Basak, N.
Caglayan, B.
Kilic, U.
Sahin, F.
Kucuk, O.
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
Cervical cancer is among the top causes of death from cancer in women. Cisplatin-based chemotherapy has been shown to improve survival; however, cisplatin treatment is associated with toxicity to healthy cells. Genistein has been used as an adjunct to chemotherapy to enhance the activity of chemotherapeutic agents without causing increased toxicity. The present study was designed to investigate the effect of genistein (25 mu M) on antitumor activity of cisplatin (250 nM) on HeLa cervical cancer cells. We have examined the alterations in expression of NF-kappa B, p-mTOR, p-p70S6K1, p-4E-BP1, and p-Akt protein levels in response to treatment. The combination of 25 mu Mgenistein with 250nM cisplatin resulted in significantly greater growth inhibition (P < 0.01). Genistein enhanced the antitumor activity of cisplatin and reduced the expression of NF-kappa B, p-mTOR, p-p70S6K1, p-4E-BP1, and p-Akt. The results in the present study suggest that genistein could enhance the activity of cisplatin via inhibition of NF-kappa B and Akt/mTOR pathways. Genistein is a promising nontoxic nutritional agent that may enhance treatment outcome in cervical cancer patients when given concomitantly with cisplatin. Clinical trials of genistein and cisplatin combination are warranted to test this hypothesis.
Description
Keywords
Citation
Sahin K., Tuzcu M., Basak N., Caglayan B., Kilic U., Sahin F., Kucuk O., -Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NF kappa B and Akt/mTOR Signaling Pathways-, JOURNAL OF ONCOLOGY, cilt.2012, 2012
Page Views

0

File Downloads

0

Sustainable Development Goals