Publication: Effects of caffeic acid phenethyl ester on wound healing in calvarial defects
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Date
2015-01-01T00:00:00Z
Authors
Authors
Kazancioglu, Hakki Oguz
Aksakalli, Sertac
AYDIN, MEHMET
Ezirganli, Seref
BEREKET, MEHMET CİHAN
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Abstract
Objective. The aim of this study is to analyze histologically the effect of CAPE on bone healing of Critical Size Defect (CSD) in rat calvaria. Study design. Thirty-two 3-month-old male rats were used. The animals were randomly divided into four groups. Group A received isotonic saline solution, Group B received CAPE (50 mmol/kg) locally, Group C received CAPE (100 mmol/kg) locally and Group D received CAPE (10 mmol/kg/day i.p. for 28 days) systematically. A 5-mm diameter calvarial defect was created in the right side of the parietal bone without damaging the underlying dura mater. Twenty-eight days after the surgery, all the animals were sacrificed. The original defect area was removed from the animal-s calvarium bone en bloc. Beginning at the center of the surgical defect, serial sections of 6 mm thick were cut longitudinally. The sections were stained with hematoxylin and eosin for analysis under a light microscope. The sections were analyzed for the presence of inflammatory infiltrate, connective tissue formation and new bone formation. Computer-assisted histomorphometic measurements were carried out with an automated image analysis system. Results. The total new bone areas were significantly greater in group D than in all groups and group C was statistically insignificant from the other groups (p 0.05), amount of total regenerated bone area than the control group. Conclusion. The results indicate that 100 mmol/kg topical and 10 mmol/kg/day systemic application of CAPE increases bone healing, especially with systemic application.
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Kazancioglu H. O. , BEREKET M. C. , Ezirganli S., AYDIN M., Aksakalli S., -Effects of caffeic acid phenethyl ester on wound healing in calvarial defects-, ACTA ODONTOLOGICA SCANDINAVICA, cilt.73, ss.21-27, 2015