Publication: The Role of Antioxidant Activity in the Prevention and Treatment of Infertility Caused by Cisplatin in Rats
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2015-01-01T00:00:00Z
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Aksoy, Ayse Nur
Kucur, Suna Kabil
Batmaz, Gonca
Gozukara, Ilay
AKSOY, Mehmet
KURT, NEZAHAT
Mammadov, Renad
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Abstract
Background/Aims:To investigate the importance of antioxidant activity in infertility caused by cisplatin in rats. Methods: Rats in cisplatin control (CG), Vitamin E+cisplatin (ECG), Vitamin C + cisplatin (CCG), Hippophae rhamnoides extract (HRE) + cisplatin (HRECG), and thiamine pyrophosphate (TPP) + cisplatin (TPPCG) groups were injected intraperitoneally (ip) with (100 mg/kg) Vitamin E, Vitamin C, HRE, and TPP, respectively. One hour later, ip cisplatin was administered (5 mg/kg), and then antioxidant medications were continued for 10 days. Cisplatin + Vitamin E (CEG-1), cisplatin + Vitamin C (CCG-1), cisplatin + HRE (CHREG-1), and cisplatin + TPP (TPPCG-1) rats received cisplatin (5 mg/kg, ip) and were kept for 10 days. At the end of that period, rats received antioxidant medications for 10 days. (n = 12, for each group). Six rats from each group were sacrificed. Ovaries were removed to measure malondialdehyde, total glutathione, glutathione S-transferase, and glutathione reductase levels. The remaining rats were kept in a suitable laboratory environment. Results: Cisplatin-induced oxidative stress was best prevented by HRE, Vitamin E, Vitamin C, and TPP, in that order. However, infertility caused by cisplatin was only prevented and treated by TPP. Conclusion: Oxidative stress is not a major component in the pathogenesis of cisplatin-associated infertility. (C) 2015 S. Karger AG, Basel
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Aksoy A. N. , Kucur S. K. , Batmaz G., Gozukara I., AKSOY M., KURT N., Mammadov R., -The Role of Antioxidant Activity in the Prevention and Treatment of Infertility Caused by Cisplatin in Rats-, GYNECOLOGIC AND OBSTETRIC INVESTIGATION, cilt.79, ss.119-125, 2015