Publication: Caloric restriction and redox homeostasis in various regions of aging male rat brain: Is caloric restriction still worth trying even after early-adulthood? Redox homeostasis and caloric restriction in brain
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2019-03-01T00:00:00Z
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YANAR, Karolin
Simsek, Bahadir
Cayli, Nisanur
Bozkir, Haktan Ovul
MENGİ, MURAT
BELCE, Ahmet
AYDIN, Seval
ÇAKATAY, Ufuk
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Abstract
Despite recent studies have shown that caloric restriction (CR) could improve some functional loss associated with brain aging, the biochemical effects of CR on brain aging are still not well understood on a quantifiable biochemical basis, including whether CR could be protective when started around middle adulthood, when age-related neurodegenerative diseases are thought to set in. Therefore, in the light of more than ever aging societies and increasing neurodegenerative diseases, we aimed to test the biochemical effects of CR on redox homeostasis in different parts of male Sprague-Dawley rat brain by using the biomarkers we consistently validated in our previous work (TOS, PCO, AOPP, AGEs, sRAGE, P-SH, LHPs, 4-HNE, TAS, Cu, Zn-SOD). Our results indicate that oxidative stress biomarkers are lower in CR group, implying a more favorable redox status that has been previously shown to be correlated with better neural function.
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YANAR K., Simsek B., Cayli N., Bozkir H. O. , MENGİ M., BELCE A., AYDIN S., ÇAKATAY U., -Caloric restriction and redox homeostasis in various regions of aging male rat brain: Is caloric restriction still worth trying even after early-adulthood? Redox homeostasis and caloric restriction in brain-, JOURNAL OF FOOD BIOCHEMISTRY, cilt.43, 2019