Publication: Predictive value of elevated D-dimer in patients undergoing primary angioplasty for ST elevation myocardial infarction
Loading...
Date
2013-10-01T00:00:00Z
Authors
Authors
Akgul, Ozgur
Uyarel, Huseyin
Pusuroglu, Hamdi
Gul, Mehmet
Isiksacan, Nilgun
Turen, Selahattin
Erturk, Mehmet
Surgit, Ozgur
ÇETİN, MUSTAFA
Bulut, Umit
Journal Title
Journal ISSN
Volume Title
Publisher
Metrics
Abstract
The aim of this study was to evaluate the prognostic value of D-dimer in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). The prognostic value of D-dimer has been documented in patients with acute coronary syndrome without ST-segment elevation. However, its value in acute ST-segment elevation myocardial infarction (STEMI) remains unclear. We prospectively enrolled 453 consecutive STEMI patients (mean age 55.6 +/- 12.4 years, 364 male, 89 female) undergoing primary PCI. The study population was divided into tertiles based on admission D-dimer values. The high D-dimer group (n=151) was defined as a value in the third tertile [>0.72ug/ml fibrinogen equivalent units (FEU)], and the low D-dimer group (n=302) included those patients with a value in the lower two tertiles (0.72ug/ml FEU). Clinical characteristics, in-hospital and 6-month outcomes of primary PCI were analyzed. The patients of the high D-dimer group were older (mean age 60.1 +/- 13.5 versus 52.4 +/- 10.6, P0.72ug/ml FEU) was found to be a powerful independent predictor of 6-month all-cause mortality (odds ratio: 10.1, 95% confidence interval: 1.24-42.73, P=0.03). These results suggest that a high admission D-dimer, level was associated with increased in-hospital cardiovascular mortality and 6-month all-cause mortality in patients with STEMI undergoing primary PCI. (C) 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Description
Keywords
D-dimer
Citation
Akgul O., Uyarel H., Pusuroglu H., Gul M., Isiksacan N., Turen S., Erturk M., Surgit O., ÇETİN M., Bulut U., et al., -Predictive value of elevated D-dimer in patients undergoing primary angioplasty for ST elevation myocardial infarction-, BLOOD COAGULATION & FIBRINOLYSIS, cilt.24, ss.704-710, 2013