Publication: Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants
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Date
2017-04-01T00:00:00Z
Authors
Authors
Daskaya-Dikmen, Ceren
Yucetepe, Aysun
Karbancioglu-Guler, Funda
Daşkaya, Hayrettin
Özçelik, Beraat
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Abstract
Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.
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Keywords
Angiotensin-I-converting enzyme inhibitory activity, Bioactive peptides, Bioavailability, Diabetes, Enzymatic hydrolysis, Obesity, Plant proteins
Citation
Daskaya-Dikmen C., Yucetepe A., Karbancioglu-Guler F., Daşkaya H., Özçelik B., -Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants-, NUTRIENTS, cilt.9, 2017