Publication:
GAS6 intron 8 c.834 + 7G > A gene polymorphism in diabetic nephropathy.

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Date
2015-06-01
Authors
ERKOÇ, R
ÇıKRıKÇıOĞLU, MA
AINTAB, E
TOPRAK, ALİ
KILIC, U
GOK, O
CETIN, AI
ZORLU, MEHMET
KıSKAÇ, MUHARREM
CAKIRCA, MUSTAFA
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Abstract
Background - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic nephropathy is prevented by warfarin-induced inhibition of GAS6 protein. It was shown that GAS6 intron 8 c.834+7G>A polymorphism is protective against type 2 diabetes mellitus, and AA genotype is associated with higher blood levels of GAS6 protein. Our aim is to investigate whether this polymorphism is a risk factor for diabetic nephropathy in type 2 diabetes mellitus. Method: Eighty-seven patients with diabetic nephropathy were compared with 66 non-diabetic controls in terms of GAS6 intron 8 c.834+7G>A polymorphism. Patients with history of stroke, ischemic heart disease were excluded. Each patient was examined by the ophthalmologist to determine diabetic retinopathy. Results: Frequency of GG, GA and AA genotypes are similar in diabetic nephropathy and control groups according to GAS6 intron 8 c.834+7G>A polymorphism (p = 0.837). Rate of diabetic retinopathy was 54.02%. In the subgroup analysis, GA genotype was significantly more frequent than GG genotype in patients with diabetic retinopathy when compared to without diabetic retinopathy (p = 0.010). Conclusion: In our study, GAS6 intron 8 c.834+7G>A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.
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diabetic nephropathy
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ERKOÇ R., ÇıKRıKÇıOĞLU M., AINTAB E., TOPRAK A., KILIC U., GOK O., CETIN A., ZORLU M., KıSKAÇ M., CAKIRCA M., et al., -GAS6 intron 8 c.834 + 7G > A gene polymorphism in diabetic nephropathy.-, Renal failure, cilt.37, ss.866-70, 2015
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