Publication:
Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS

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Date
2020-01-01T00:00:00Z
Authors
DİNCEL, DEMET
Olgan, Hatice
Canbaloglu, Zeynep
Yalcin, Sule
Erkucuk, Aysen
TIRIS, GİZEM
GÖREN, AHMET CEYHAN
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Abstract
Adulterations of dietary supplements are serious threats to public health in all around of world. Nowadays, in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial or harmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicin in dietary supplements via Fortis C18 (150 x 3 mm; 3 mu m) column at 25 degrees C was developed and validated in a mixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formic acid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min. The recoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 for dihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplements products for adulteration to increase the effects of product without any declaration.
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DİNCEL D., Olgan H., Canbaloglu Z., Yalcin S., Erkucuk A., TIRIS G., GÖREN A. C. , -Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS-, JOURNAL OF CHEMICAL METROLOGY, cilt.14, ss.77-82, 2020
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