Publication: High D-dimer levels are associated with prostate cancer
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Date
2020-05-01T00:00:00Z
Authors
Authors
KALKAN, Senad
Caliskan, Selahattin
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Journal ISSN
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Abstract
Prostate cancer is one of the most common types
of cancer among men in the world1
and a significant
health problem in developed and developing countries2
. The association between cancer and hemostasis has been shown in several studies3
. The main risk
factors for coagulation activation and thrombosis are
aging and malignancy4
. The increased risk of thrombosis in cancer patients may be associated with high
levels of coagulation markers (fibrinogen), and thrombogenesis markers (D-dimer) are likely evidence of
this process5
.
Fibrinogen is an acute-phase protein that is mainly
synthesized by hepatocytes and converted into insoluble fibrin by activated thrombin. It is also an important indicator of the coagulation system6
. The plasma
fibrinogen level increases in some circumstances,
such as malignancy and systemic inflammation.
D-dimer is a degradation product of fibrin which is
produced by plasmin-induced fibrinolytic activity7
. It
is a biomarker that indicates the activation of hemostasis and fibrinolysis. Elevated plasma levels may
be associated with some scenarios such as cancer,
pregnancy, infectious diseases, trauma, surgery, and
venous thromboembolism.
When fibrinogen levels are increased, they are
deemed to be an unfavorable prognostic factor in some
malignancies, such as those of the digestive system,
gynecologic malignancies, urologic neoplasms, and
soft tissue sarcomas6
. A high level of D-dimer is a prognostic factor associated with increased mortality risk
in patients with brain tumors, lymphomas, breast,
lung, stomach, colorectal, pancreatic, and prostate
cancers7
. We investigated the levels of D-dimer and
fibrinogen in patients with prostate cancer and benign
prostate hyperplasia.
Description
Keywords
Prostate cancer, Cancer
Citation
KALKAN S., Caliskan S., -High D-dimer levels are associated with prostate cancer-, REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, cilt.66, ss.649-653, 2020