Publication: The relationship of Serum Histone H3.3 and H4 with chronic Hepatitis B
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Date
2020-09-01T00:00:00Z
Authors
Sümbül, Bilge
Şentürk, Hakan
Köker, İbrahim Hakkı
Koçhan, Koray
İnce, Ali Tüzün
Biberci Keskin, Elmas
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Abstract
Objective: To determine the role of serum histone H3.3 and H4 in patients with chronic hepatitis B to explore any relationship between the two.Methods: The prospective controlled clinical pilot study was conducted in the Gastroenterology Clinic of Bezmialem Vakif University, Istanbul, Turkey, from January to October 2017, and comprised biopsy-proven patients with chronic hepatitis B and healthy controls. Demographics, hepatitis B virus deoxyribonucleic acid quantity, hepatitis B e-antigen, aspartate aminotransferase, alanine transaminase, international normalized ratio, total/direct bilirubin, albumin and thrombocyte counts as well as histological activity index and fibrosis scores were noted. Data was analysed using SPSS 22.Results: Of the 140 subjects, 70(50%) each were cases and controls. The overall mean age of the sample was 43.38±15.07 years (range: 18-70 years). There was positive correlation of histone H3.3 with hepatitis B virus deoxyribonucleic acid, aspartate aminotransferase, alanine transaminase and international normalized ratio levels. Histone H4 levels only correlated with hepatitis B virus deoxyribonucleic acid and international normalized ratio. Hepatitis B e-antigen positivity was present in 14(20%) of the cases.Conclusion: Histone H3.3 levels appeared to be associated with pathophysiological changes in chronic hepatitis B patients, suggesting that future treatments should target H3.3.Keywords: Histone H3.3, Histone H4, Extracellular histone, Chronic Hepatitis B, HBV.(JPMA 70: 1596; 2020)DOI:https://doi.org/10.5455/JPMA.19365
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Keywords
Histone H3.3, Histone H4, Extracellular histone, Chronic Hepatitis B, HBV
Citation
İnce A. T. , Biberci Keskin E., Sümbül B., Koçhan K., Köker İ. H. , Şentürk H., -The relationship of Serum Histone H3.3 and H4 with chronic Hepatitis B-, JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, cilt.70, ss.1596-1600, 2020