Publication: Endokan ve ateroskleroz risk faktörleri arasındaki ilişki / Relationship between endocan and atherosclerotic risk factors
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Date
2017
Authors
Authors
AİLİA DAE, Shute
Journal Title
Journal ISSN
Volume Title
Publisher
Bezmialem Vakıf University
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Abstract
Background: Endothelial dysfunction plays an important role in the pathophysiology of
atherosclerosis and coronary artery disease (CAD). Previous studies suggested that human
endothelial cell-specific molecule-1 (endocan) may be a novel endothelial dysfunction
marker. This study aims to investigate the relationship between serum endocan concentration
and atherosclerosis and relationship between serum endocan level and individual factors used
to calculate 10 year risk of heart disease using ASCVD(Atherosclerotic Cardiovascular
Disease) estimator.
Methods: A total of 205 eligible patients were enrolled in this study. Serum endocan level
was measured by enzyme-linked immunosorbent assay. Ten year risk of atherosclerotic heart
disease were calculated for induvidual patients online using ASCVD risk estimator.
Results: Backward linear regression analysis showed no correlation between serum endocan
level and individual factors(age, gender, sytolic and diastolic blood pressure, smoking status,
use of antihypertensive drugs) used to calculate ten year risk for coronary artery disease in
ASCVD estimator. There was also no raltionship between serum endocan level and
atherosclerosis.
Conclusions: There was no significant realtionship between serum endocan concentration and
atherosclerosis. We also found no correlation between serum endocan level and individal risk
factors for atherosclerotic heart diseases used in ASCVD risk estimator.
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Description
Thesis (Medical)--Bezmialem Vakıf University, Faculty of Medicine, Department of Internal Medicine, Istanbul, 2017
Keywords
Kardiyoloji = Cardiology