Publication: Effect of cerebral microhemorrhages on neurocognitive functions in patients with end-stage renal disease.
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Date
2020-08-05T00:00:00Z
Authors
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Atay, M
Alkan, A
Toprak, H
Halac, G
Erkoc, R
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Abstract
Background: Death is the most serious complication of intracerebral hemorrhage. Microbleeding can be a precursor of intracerebral hemorrhage. Susceptibility weighted imaging (SWI) should be included in imaging protocols for some specific groups such diabetic hemodialysis patients in terms of prediction of macrohemorrhages.
Purpose: To investigate intracerebral microbleeding in hemodialysis patients and the correlation between microbleeding and neurocognitive impairment.
Material and Methods: Forty-nine hemodialysis cases were involved in the study. Locations of microbleeding, correlation between microbleeding and hypertension, diabetes mellitus (DM), age, and duration of dialysis were analyzed. Standardized mini-mental test was performed. The tested cases were divided into two groups: intracerebral microbleeding (group 1, n¼26) and without intracerebral microbleeding (group 2, n¼17).
Results: Incidence of microbleeding and macrohemorrhage was noted as 59% and 14%, respectively, in all cases. All macrohemorrhagic cases also have microbleeding. In group 1, neurocognitive impairment was detected in 10 (38.4%) cases: six and four cases with moderate and mild impairment, respectively. In group 2, neurocognitive impairment was detected in 2 (11.7%) cases, both with mild impairment. A significant positive correlation was detected between microbleeding and neurocognitive impairment (P¼0.031). Although there was no correlation between attention
disorder and microbleeding, a positive correlation was detected between close memory impairment and microbleeding (P¼0.027). A positive correlation was detected between DM and microbleeding (P¼0.027).
Conclusion: In hemodialysis patients, microbleeding can be a cause of neurocognitive impairment which will be important for guide to treatment protocols. SWI should be included in the imaging protocol of diabetic hemodialysis patients with neurocognitive deterioration.
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Keywords
Hemodialysis, susceptibility weighted imaging, microbleeding
Citation
Atay M., Alkan A., Toprak H., Halac G., Erkoc R., -Effect of cerebral microhemorrhages on neurocognitive functions in patients with end-stage renal disease.-, Acta radiologica (Stockholm, Sweden : 1987), 2020