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Targeted Nanomedicines for Cancer Therapy, From Basics to Clinical Trials

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Date
2020-04-01
Author
Armuzzi, Alessandro
Novacek, Gottfried
Reinisch, Walter
Johnson, Scott
Buessing, Marric
Neimark, Ezequiel
Petersson, Joel
Lee, Wan-Ju
D'Haens, Geert R.
Panaccione, Remo
Colombel, Jean-Frederic
Travis, Simon P. L.
Bossuyt, Peter
Baert, Filip
Vanasek, Tomas
Danalioglu, Ahmet
Advisor
Type
Article
Metadata
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Abstract
Traditional systemic chemotherapy involves the wide distribution of drug molecules in the body, causing toxic side effects in the healthy tissues and limiting the therapeutic dose required at the site of drug action. In order to decrease side effects and increase the drug efficacy, recent research on chemotherapy focuses on drug targeting. Targeted therapy can be achieved by several mechanisms including; 1) using an antibody as a drug that is specific to a disease biomarker, 2) using an antibody (or peptide) as a targeting agent conjugated to the drug molecule, 3) delivering the drug molecules to the target tissue in a nano-carrier with or without the targeting agent attached on its surface. The third approach involves the nanomedicines that can be targeted to diseased tissues by both passive (extravasating at diseased sites due to leaky vasculature) and active (specific interaction of the targeting agent with disease biomarker) targeting mechanisms. In this review we will cover the passively targeted nanomedicines prepared using nano drug carriers. Ideally the carrier particle should be in the right size (1-100nm), stable enough to prevent drug leakage during circulation, and safe not to cause any damage to healthy tissues. Competition for all these properties generated many different types of materials to be used as nanodrug delivery systems. After a brief review of most commonly used drug carriers, we discuss the clinical use of the targeted nanomedicines with regard to their pharmacokinetic and pharmacodynamics properties, and how these properties vary from conventional formulations providing free drugs in the circulation after administration.
Subject
Eskandari Z., BAHADORİ F., ÇELİK B., Onyuksel H., -Targeted Nanomedicines for Cancer Therapy, From Basics to Clinical Trials-, JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, cilt.23, ss.132-157, 2020
URI
https://hdl.handle.net/20.500.12645/18077
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  • PubMed İndeksli Yayın Koleksiyonu [3700]
  • Scopus İndeksli Yayınlar Koleksiyonu [4458]
  • WoS İndeksli Yayınlar Koleksiyonu [5222]
  • Yayınlar - Eserler [10057]

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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS