Publication: Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer.
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Date
2020-03-19T00:00:00Z
Authors
Sahbaz, C
Elbay, AHMET
Ozcelik, M
Ozdemir, H
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Abstract
Sleep may play a fundamental role in retinal regulation and the degree of retinal variables.
However, no clinical study has investigated optical coherence tomography (OCT) parameters in
patients with primary insomnia. All participants were evaluated with the insomnia severity index
(ISI) and the Pittsburgh sleep quality index (PSQI). The retinal nerve fiber layer (RNFL), ganglion cell
layer (GC), inner plexiform layer (IPL), macula and choroidal (CH) thickness were compared between
52 drug-naïve patients with primary insomnia and 45 age-gender-BMI-smoke status matched healthy
controls (HC). The patients with primary insomnia differed from the HC regarding RNFL-Global
(p = 0.024) and RNFL-Nasal inferior (p = 0.010); IPL-Temporal (p < 0.001), IPL-Nasal (p < 0.001);
CH-Global (p < 0.001), CH-Temporal (p = 0.004), CH-Nasal (p < 0.001), and CH-Fovea (p = 0.019).
ISI correlated with RNFL-Global and RNFL-Nasal inferior. The regression analysis revealed that
ISI was the significant predictor for the thickness of RNFL- Nasal inferior (p = 0.020), RNFL-Global
(p = 0.031), and CH-Nasal (p = 0.035) in patients with primary insomnia. Sleep disorders are seen
commonly in patients with psychiatric, including ocular diseases. Adjusting the effect of insomnia
can help to clarify the consistency in findings of OCT.
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Citation
Sahbaz C., Elbay A., Ozcelik M., Ozdemir H., -Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer.-, Brain sciences, cilt.10, 2020