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dc.contributor.authorZeybek, Cigdem Aktuglu
dc.contributor.authorAtaman, Yasemin
dc.contributor.authorCESUR, Yaşar
dc.contributor.authorKaracabey, Burcin Nazli
dc.contributor.authorDemirkol, Demet
dc.contributor.authorSoysal, Elif
dc.date.accessioned2020-04-07T20:59:15Z
dc.date.available2020-04-07T20:59:15Z
dc.date.issued2019-01-01T00:00:00Z
dc.identifier.urihttps://hdl.handle.net/20.500.12645/16271
dc.description.abstractBackground: The objective of this study is to investigate the efficacy of continuous renal replacement therapy (CRRT), mainly continuous venovenous hemodiafiltration (CVVHDF), and evaluate vasoactive requirements in hyperammonemic neonates and infants. Methods: Patients who underwent CRRT for hyperammonemia were retrospectively analyzed. Measurements and Main Results: Patients in 7 of the encounters were treated solely by CVVHDF. During 3 encounters, patients who received continuous venovenous hemodialysis (CVVHD) were transitioned to CVVHDF. CVVHD was used in 3 encounters. The median 50% reduction time for ammonia was 8 h (range 3-15 h). The median duration of CRRT treatment was 40 h (range 24-89 h). Survival to hospital discharge occurred in 12 encounters (92.3%). Eleven encounters (84.6%) were treated with different vasoactive agents. In those encounters, the median vasoactive medications- start time was the 6th hours (range 2-60 h) of CRRT. There was no association between the vasoactive index score and pre-dialysis ammonia concentration. Conclusions: CRRT achieves timely control of hypeammonemic states. Hemodynamic instability necessitating intervention with vasoactive medications is a common finding in patients with hyperammonemia.
dc.subjectDemirkol D., Zeybek C. A. , Karacabey B. N. , CESUR Y., Ataman Y., Soysal E., -The Role of Supportive Treatment in the Management of Hyperammonemia in Neonates and Infants-, BLOOD PURIFICATION, cilt.48, ss.150-157, 2019
dc.titleThe Role of Supportive Treatment in the Management of Hyperammonemia in Neonates and Infants
dc.typeArticle
dc.identifier.wosWOS:000480263700009
dc.identifier.scopus85065623614
dc.identifier.doi10.1159/000495021
dc.identifier.pubmed31067532
local.publication.isinternational1


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