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Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

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Date
2017-08-01T00:00:00Z
Authors
Cemil, BC
Yilmazer, D
Atas, H
Cengiz, Fatma Pelin
Canpolat, F
Alper, M
Gonul, M
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Abstract
Introduction: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. Aim: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. Material and methods: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group. Results: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients. Conclusions: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.
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Cemil B., Yilmazer D., Atas H., Cengiz F. P. , Canpolat F., Alper M., Gonul M., -Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?-, Postepy dermatologii i alergologii, cilt.34, ss.322-327, 2017
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