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Publication Metadata only Prevalance of Urinary Incontinence and Anal Incontinence: An Internet Based Cross-Sectional Study of Female Turkish University Students(2023-10-01) GÖKMEN KARASU A. F.; Cetin C.; PASİN Ö.; Karacabay M.; Tanoglu F. B.; Ilhan G.; GÖKMEN KARASU, AYŞE FİLİZ; PASİN, ÖZGEPublication Metadata only KAPOSIFORM HEMANGIOENDOTHELIOMA AND REFRACTORY KASABACH-MERRITT PHENOMENON TREATED WITH SIROLIMUS(2023-11-01) EREN T.; ÇAKIR F. B.; ÇAKIR, FATMA BETÜLPublication Metadata only Development of a green high-performance liquid chromatography method for tofacitinib quantification in pharmaceutical formulations and degradation studies(2024-04-02) TIRIS G.; Genc A. A.; ERK N.; TIRIS, GİZEMA new high-performance liquid chromatography (HPLC) method was applied for the quantification of the active substance of tofacitinib. Analysis was performed on a Chromasil 100 C18 (100.0 x 4.0 mm, 3.5 mu m) stationary phase. The mobile phase consisted of acetonitrile:0.2% phosphoric acid in water (12:88, v/v). The prepared sample (20.0 mu L) was injected into the system. A detection wavelength of 285.0 nm was chosen for the compound, and the flow rate was 0.8 mL/min. The experiment was completed in 5.0 min. The analysis temperature was set to 40.0 degrees C. The method was evaluated using green chemistry. The method was validated according to the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines. For linearity studies calibration curves were constructed in the range of 10.0-200.0 mu g/mL. The recovery values were calculated at 97.66% and 105.68%. The method developed for the analysis of the active substance had a short analysis time and was cost-effective. It is an environmentally friendly method due to the mobile phase content used. The technique can be used in laboratory analysis and bioequivalence experiments.Publication Metadata only EARTHQUAKE DISASTER AND ITS' ACUTE EFFECT ON PEDIATRIC HEMATOLOGY AND ONCOLOGY.IN TURKIYE; TURKISH PEDIATRIC ONCOLOGY GROUP-TPOG QUESTIONARE STUDY(2023-11-01) TAÇYILDIZ N.; İNCESOY ÖZDEMİR S.; Kupeli B.; Cemaloglu M.; Acipayam C.; Oncel K.; Akinel A. N.; Karabel N.; Coskun C.; SEZGİN G.; et al.; ÇAKIR, FATMA BETÜLPublication Metadata only Management preferences of orthopedic surgeons in developmental dysplasia of the hip under 1 year of age in Türkiye: Results of a nationwide cross-sectional survey(2023-11-01) Cetin B. V.; Bakircioglu S.; Ciftci S.; Soylemez M. S.; Erkus S.; TURHAN Y.; Camurcu I. Y.; Duman S.; Yildirim T.; MEMİŞOĞLU K.; et al.; ŞENARAN, HAKANObjective: This study aimed to evaluate the diagnosis and treatment preferences of orthopedic surgeons in developmental dysplasia of the hip (DDH) cases under the age of 1 in Turkiye with a higher incidence of DDH, estimated to be around 5-15 per 1000 live births. Methods: This was a nationwide cross-sectional survey. A link for the online survey, including 16 multiple-choice questions, was sent to the email group of the National Orthopedic Society. Results: Among 233 filled -out surveys, 211 met the inclusion criteria. Half of the participants had experience of 25 DDH cases per year. Over one-third used both anterior and medial approach open reduction, but a trend to anterior open reduction alone was more evident in surgeons treating >50 DDH cases per year. More experienced surgeons were more prone to check the intraoperative reduction with postoperative computed tomography or magnetic resonance imaging. Diagnosis and treatment ages of DDH cases did not significantly change during the coronavirus disease 2019 pandemic. Conclusion: Management preferences of orthopedic surgeons in DDH before walking age primarily depend on the rate of pediatric patients in daily practice and the number of treated DDH cases per year.Publication Metadata only The relationship between nutritional status and white matter integrity in older adults: A diffusion tensor imaging study.(2024-04-01) Atasoy B.; Balsak S.; Alkan A.; Akcay A.; Peker A. A.; Toluk O.; Atila N.; Kaya A.; Ipar O.; Soysal P.; ATASOY, BAHAR; ALKAN, ALPAY; AKÇAY, AHMET; TOLUK, ÖZLEM; ATİLA, NAZ; İPAR, ÖZLEM; SOYSAL, PINARPublication Metadata only D VİTAMİNİ İLE MİYOKARD İNFARKTÜSÜ ARASINDAKİ İLİŞKİ(Eğitim Kitabevi, 2024-04-01) Çalıkoğlu A.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEGİRİŞ Hastalık durumları iki sebepten dolayı ortaya çıkmakta olup bunları bulaşıcı olan ve bulaşıcı olmayan hastalıklar olarak ikiye ayrılmaktadır (Budreviciute et al., 2020). Ülke zenginliklerinin teknolojik, ekonomik ve daha farklı yönlerden eksiklik içerisinde bulunduğu eski dönemlerde morbidite ve mortalite sebepleri incelendiğinde ulaşılan gerçek bulaşıcı hastalıklar kaynaklı olduğudur. Ancak, günümüzde bu durumun bulaşıcı olmayan hastalıklara dönüştüğü çalışmalarda bildirilmiş; insanlar arasında \"soylu ve seçkin hastalığı\" olarak tanımlanmıştır ADDIN EN.CITE (Wang & Wang, 2020) 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Bulaşıcı olmayan hastalıklar, vücudun kendini koruması adına adaptif bir mekanizma geliştirmesi ancak uzun süreli olarak bu durumun devam etmesiyle patolojik durumların ortaya çıkmasıdır. Gelir düzeyi yüksek ülkelerde fiziksel aktivite gerek iş hayatı kaynaklı gerek teknolojinin gittikçe artmasından kaynaklı azalma göstermektedir. Aynı zamanda besinlerin ani enerji yüklemesi yapacak şekilde üretilmesi bu bağlamda fazla miktarda rafine şeker, doymuş yağ, yüksek tuz ve az posalı şekilde işlenerek tüketime sunulmaktadır (Budreviciute et al., 2020). Böyle gıdaları tüketen bireylerherhangi bir tokluk sağlayacak besini vücuduna alamamaktadırlar. Bu sebepten, içerisinde bulunan birçok katkı maddesinin de etkisini göz önünde bulundurduğumuzda bu tür besinleri daha fazla tüketmek istemelerine ve vücut kitle indekslerinin yükselmesine sebep olur. Ardından ortaya çıkan bulaşıcı olmayan hastalıklar ise başta hipertansiyon, Tip 1 ve 2 diyabet, kardiovasküler hastalıklar, solunum yolu hastalıkları, kanserler ve böbrek hastalıklarıdır ADDIN EN.CITE (Vaduganathan et al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En çok ölüme neden olan bulaşıcı olmayan hastalıklar arasında ilk dört öldürücü hastalık kardiyovasküler hastalıklar (yılda 17,9 milyon ölüm), kanserler (9,0 milyon), solunum yolu hastalıkları (3,9 milyon) ve diyabettir (1,6 milyon) ADDIN EN.CITE ADDIN EN.CITE.DATA 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(Budreviciute et al., 2020) 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.Publication Metadata only An evaluation of a hepatotoxicity risk induced by the microplastic polymethyl methacrylate (PMMA) using HepG2/THP-1 co-culture model(2024-04-01) Boran T.; Zengin Ö. S.; Şeker Z.; Günaydın Akyıldız A.; Kara M.; Öztaş E.; Özhan G.; ŞEKER, ZEHRA; GÜNAYDIN AKYILDIZ, AYŞENURPublication Metadata only METABOLOMIC PROFILING IN DISTINCT TYPES OF LEUKEMIA(2024-02-29) Gül A. Z.; Selek Ş.; Bekiroğlu S.; Demirel M.; Çakır F. B.; Uyanık B.; SELEK, ŞAHABETTİN; DEMİREL, METİNPublication Metadata only METABOLIC EFFECTS OF ORAL TITANIUM DIOXIDE IN JUVENILE RATS: INSIGHTS FROM NMR-BASED METABOLOMICS ANALYSIS(2024-02-29) KÖKTAŞOĞLU F.; DEMİREL M.; GÜLTEKİN F.; GÜLER E. M.; BEKİROĞLU S.; SELEK Ş.; KÖKTAŞOĞLU, FATMANUR; DEMİREL, METİN; SELEK, ŞAHABETTİNPublication Metadata only Association Between Articular Eminence Structure and Joint Spaces in Temporomandibular Joints with Anterior Disc Displacement(2024-03-01) ETÖZ M.; Çabuk D. S.; KÜTÜK N.; ERCAN İ.; KÜTÜK, NÜKHETBackground and Aims: The association among the joint spaces, articular eminence morphology, and disc displacement is not well documented in the literature. This study aims to evaluate and compare the joint spaces and the articular eminence structure (eminence height [E h] and inclination [E i]) using cone-beam computed tomography (CBCT) of temporomandibular joints (TMJs) with anterior disc displacements and joints with normal disc position. Methods: The study groups consisted of 75 TMJs of 39 patients. The disc status of TMJs was diagnosed with magnetic resonance imaging, and the measurements were performed on CBCT. Three groups, that is, normal disc position (NDP) group, anterior disc displacement with reduction (ADDWR) group, and anterior disc displacement without reduction (ADDWoR) group, were established. Anterior, superior, posterior joint spaces (AJS, SJS, and PJS, respectively), articular E h, and articular E i were measured. Statistical Package for the Social Sciences version 22 was used for statistical analysis. Shapiro-Wilk test was used to check the normality of data. Intergroup comparisons of categorical variables were assessed with Fisher-Freeman-Halton test. For comparison of continuous variables parameters, Mann-Whitney U test and Kruskal-Wallis test were used. Statistical significance level was determined as P < 0.05. Results: Significant differences were not found in intergroup comparisons for PJS. However, the difference between groups was found to be significant for AJS, SJS, E h, and E i. Intergroup comparisons were performed for these parameters. No significant difference was found between the NDP group and the ADDWR group for AJS, SJS, E h, and E İ. The mean AJS, SJS, E h, and E i values in ADDWoR were found to be significantly lower compared to the corresponding values in both NDP and ADDWR groups. Conclusion: Decreased AJS and SJS when TMJ is evaluated with CBCT may be an indicator of ADDWoR. Authors suggest that narrowed articular E i and reduced articular E h can be one of the predisposing factors for anterior disc displacement.Publication Metadata only Dosing-time, feeding, and sex-dependent variations of everolimus pharmacokinetics in mice(2024-01-01) ÖZTÜRK CİVELEK D.; ÖZTÜRK SEYHAN N.; AKYEL Y. K.; Gazioglu I.; PALA KARA Z.; Orman M. N.; OKYAR A.; ÖZTÜRK CİVELEK, DİLEK; GAZİOĞLU, IŞILBackground: Everolimus is an oral mammalian target of rapamycin (mTOR) inhibitor used as an immunosuppressant and anticancer. Its pharmacokinetics is highly variable, it has a narrow therapeutic window and shows chronotoxicity with the best time at ZT13 and worst time at ZT1 (ZT; Zeitgeber time, time after light onset) in the preclinical setting. Objectives: In the present study, we aimed to investigate whether the pharmacokinetics of everolimus vary according to dosing time and whether sex and feeding status interfere with the chronopharmacokinetics. Method: A single dosage of 5 mg/kg everolimus was administered orally to C57BL/6J male and female mice, in fed or fasted states at ZT1-rest and ZT13-activity times and blood and tissue samples were collected at 0.5, 1, 2, 4, 12, and 24 h following drug administration. Ileum, liver, plasma, and thymus concentrations of everolimus were determined. Results: Females had a greater ileum AUC0–24h than males when fed (P = 0.043). Everolimus AUC0–24h in the liver was substantially greater at ZT1 than at ZT13 in a fasted state (P = 0.001). Plasma Cmax, AUC0–24h, and AUCtotal were not statistically significant between the groups (P = 0.098). In one of the target organs of everolimus, the thymus, males had considerably higher amounts at ZT1 than females (P = 0.029). Conclusion: Our findings imply that the pharmacokinetics of everolimus in mice may differ according to dosing time, sex, and feeding. Greater tissue distribution of everolimus at ZT1 may be associated with the worst tolerated time of everolimus. Our research suggests that oral chronomodulated everolimus therapy may be more effective and safer for cancer patients.Publication Metadata only Diagnostic and Prognostic Value of Pentraxin 3, Interleukin-6, CRP, and Procalcitonin Levels in Patients with Sepsis and Septic Shock(2024-03-01) Palalioǧlu B.; Erdoǧan S.; Atay G.; Tugrul H.; ÖZER Ö. F.; ÖZER, ÖMER FARUKIntroduction and Purpose: In this prospective study, we aim to evaluate the effects of antibiotherapy on pentraxin-3 (PTX3), C-reactive protein (CRP), and interleukin-6 (IL-6) levels in patients with sepsis and septic shock. Materials and Methods: In our study, CRP, procalcitonin, IL-6, and PTX3 levels at initial and 48 hours of the antibiotherapy of patients who were admitted to the pediatric intensive care unit (PICU) with the diagnosis of sepsis and septic shock between June 2020 and March 2021 were compared. Patients were compared with the age-appropriate case-control group formed from the patients who received pre-operative routines to investigate the diagnostic value. Results: CRP, IL-6, and PTX3 levels of the patients were significantly higher compared to controls (P 32 pg/mL, 88.9% sensitivity, 65.6% specifity). Conclusion: The results of this study indicated that IL-6 level is an appropriate biomarker with high specificity in the diagnosis of sepsis and septic shock and in evaluating the response to treatment and determining the prognosis.Publication Metadata only The missing part of the past, current, and future distribution model of Quercus ilex L.: the eastern edge(2024-04-01) YILMAZ O. Y.; AKKEMİK Ü.; Doğan Ö. H.; YILMAZ H.; SEVGİ O.; SEVGİ E.; SEVGİ, ECEOngoing climate change is anticipated to shift the geographical distribution range and impact local abundance of tree species by altering their ecological conditions. Given the lower resilience of populations at the species’ range edges, locally adapted range-edge populations are critical to the species’ survival under climate change. In this context, the distribution of holm oak (Quercus ilex L.) at the eastern border of its distribution range was assessed under current, past, and foreseeable future climate change scenarios, using species distribution models (SDMs). Current SDMs were developed using World-Clim 1.4 climate data as baseline at 30-second spatial resolution by using Generalized Boosted Regression Models (GBM) and showed moderate model performance. To compare temporal transferability and account for climate uncertainties of two versions of future climate data (CMIP5 and CMIP6), we used 4 Global Circulation Models (GCMs), 2 emission scenarios (moderate RCP45/SSP245 and pessimistic – RCP85/SSP585) for 2 different periods in the future (2040-2060 and 2060-2080). We also made predictions about the past (Mid-Holocene, about 6,000 years ago) using 4 CMIP5 GCMs. Most important variables of SDMs were distance to the sea, isothermality (BIO3), annual precipitation (BIO12), the mean temperature of driest quarter (BIO9), and the precipitation of driest month (BIO14). Our findings showed that the species’ potential distribution range probably used to be much wider in the mid-Holocene, which implies that the holm oak had a broader climatic niche during this period. The future projections indicate that its distribution area in the eastern border might increase particularly in the Black Sea region, while decreasing in the Aegean region resulting in a likely northward range shift in Turkey. However, other variables not included in our models such as land use changes might drive future shifts. Due to its high resistance to dry conditions and resilience, this species might continue to spread in southwestern Turkey in 2050s and 2070s. Finally, our study fills the gap in potential distribution predictions in context of climate change for the eastern boundary of the holm oak.Publication Metadata only The metameric effect of monolithic zirconias with varying yttrium ratios(2024-01-01) Güven M. E.; KARA Ö.; GÜVEN, MEHMET EJDER; KARA, ÖZLEMPURPOSE. To evaluate the metameric disparities among monolithic zirconia materials with differing yttrium compositions across various lighting conditions. MATERIALS AND METHODS. Thirty-six square-shaped zirconia samples measuring 10 X 10 X 0.5 mm were prepared from monolithic zirconia materials with three different yttrium contents. A 0.2 mm thick layer of polymerized dual-polymerizable self-adhesive resin cement was created using a silicone mold with the same dimensions as the prepared zirconia specimens. To evaluate metamerism, color measurements were conducted using a spectrophotometer device on a neutral gray background in a color measurement cabinet that offers four different illumination environments. All samples underwent aging by subjecting them to 10000 thermal cycles using a thermal cycle tester. Following thermal aging, color measurements were taken once more, and the data were recorded using the CIE L*, a*, b* color system. Two-way ANOVA and Post-hoc Bonferroni tests were employed to analyze the data. RESULTS. It was observed that there was no statistical difference among the color measurements made in different illumination environments of the monolithic zirconia ceramics used to evaluate metamerism P(>. 05). This observation remained consistent both before and after thermal aging. After thermal aging, the color of monolithic zirconia materials exhibited a tendency towards red and yellow hues, accompanied by a decrease in brightness levels. CONCLUSION. It can be stated that different illumination conditions did not affect the metamerism of monolithic zirconia materials, but there was a color change in monolithic zirconia materials after a thermal aging period equivalent to one year. [J Adv Prosthodont 2024;16:48-56]Publication Metadata only An in vitro analysis of an innovative standardized phospholipid carrier-based Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions(2024-01-01) KARA M.; Sahin S.; Rabbani F.; ÖZTAŞ E.; Hasbal-Celikok G.; KANIMDAN E.; KOÇYİĞİT A.; Kanwal A.; Wade U.; Yakunina A.; et al.; KANIMDAN, EBRU; KOÇYİĞİT, ABDÜRRAHİMBackground: Melissa officinalis L. (MO), commonly known as lemon balm, a member of the mint family, is considered a calming herb. In various traditional medicines, it has been utilized to reduce stress and anxiety and promote sleep. A growing body of clinical evidence suggests that MO leaf extract supplementation possesses considerable neuropharmacological properties. However, its possible mechanism of action largely remains unknown. Objective: In the present in vitro studies, we comparatively investigated the central nervous system (CNS)-calming and antioxidative stress properties of an innovative standardized phospholipid carrier-based (Phytosome™) MO extract (Relissa™) vs. an unformulated dry MO extract. Methods: The neuropharmacological effect of the extract was studied in the anti-depressant enzymes γ-aminobutyrate transaminase (GABA-T) and monoamine oxidase A (MAO-A) assays and SH-SY5Y cells brain-derived neurotrophic factor (BDNF) expression assay. The neuroprotective effect of the extract against oxidative stress was assessed in SH-SY5Y cell-based (H2O2-exposed) Total Antioxidant Status (TAS) and Total Reactive Oxygen Species (ROS) assays. The cytotoxic effect of the extract was evaluated using MTT and LDH assays. The extract antioxidant effect was also evaluated in cell-free chemical tests, including TEAC-ABTS, DPPH, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Antioxidant Capacity (ORAC), and Hydroxyl Radical Antioxidant Capacity (HORAC) assays. Results: Relissa™ exhibited high GABA-T inhibitory activity, IC50 (mg/mL) = 0.064 vs. unformulated dry MO extract, IC50 (mg/mL) = 0.27. Similar inhibitory effects were also observed for MAO-A. Relissa™ demonstrated an improved neuroprotective antioxidant effect on SH-SY5Y cells against H2O2-induced oxidative stress. Compared to unformulated dry MO extract, Relissa™ exerted high protective effect on H2O2-exposed SH-SY5Y cells, leading to higher cells BDNF expression levels. Moreover, cell-free chemical tests, including TEAC-ABTS, DPPH radical scavenging, FRAP, ORAC, and HORAC assays, validated the improved antioxidant effect of Relissa™ vs. unformulated dry MO extract. Conclusion: The results of the present study support the neuromodulating and neuroprotective properties of Relissa™, and its supplementation may help in the amelioration of emotional distress and related conditions.Publication Metadata only Tranexamic Acid and Rhinoplasty: How Do Different Administration Routes Affect Effectiveness?(2024-03-27) Sezen Göktaş S.; Yenigün A.; Sütcü A. O.; Özturan O.; Tuğrul S.; YENİGÜN, ALPERPublication Metadata only THE THYROID FUNCTION IN PATIENTS WITH FIBROMYALGIA SYNDROME(2024-04-30) Sönmez S.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEAlthough the medical treatment and etiology of fibromyalgia are not fully understood, its effects on patients are considerable. Various symptoms such as chronic pain, fatigue, depression, sleep disturbances, and cognitive issues can significantly impact the quality of life of patients. In this context, the potential relationship between fibromyalgia and nutrition will be explored in this section. Studies examining the role of nutrient supplements in fibromyalgia suggest that dietary changes can reduce fibromyalgia symptoms and alleviate pain, implying potential positive effects. However, it has also been demonstrated that certain dietary components may increase the risk of fibromyalgia or exacerbate symptoms. Particularly, it has been noted that glutamate excitotoxin, a common food additive, may increase central pain sensitivity in individuals. Fibromyalgia is a common condition among rheumatic diseases and shares similarities with autoimmune thyroid diseases, especially hypothyroidism. Therefore, autoimmune thyroid disease, hypothyroidism, and Hashimoto\"s thyroiditis are also discussed in this work. Additionally, studies addressing the relationship between fibromyalgia diagnosis and treatment methods and thyroid diseases, one of the differential diagnoses, are compiled. In conclusion, advanced clinical research is needed to better understand the pathophysiological connection between fibromyalgia syndrome and thyroid diseases. Keywords: Fibromyalgia, Diagnosis and treatment, Nutrition, Autoimmune thyroiditisPublication Metadata only Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy(2024-03-01) Gençoğlu Katmerlikaya T.; Ersen B. C.; Dağ A.; Sancakli B.; Ozgen P. S. O.; Yalcin E. K.; Avci B.; DAĞ, AYDANPublication Metadata only HER YÖNÜYLE ANATOMİ 4. BASKI (baskıda)(İstanbul Tıp Kitabevi, 2024-05-01) Arifoğlu Y.; ARİFOĞLU, YASİN