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Publication Metadata only Tranexamic Acid and Rhinoplasty: How Do Different Administration Routes Affect Effectiveness?(2024-03-27) Sezen Göktaş S.; Yenigün A.; Sütcü A. O.; Özturan O.; Tuğrul S.; YENİGÜN, ALPERPublication Metadata only THE THYROID FUNCTION IN PATIENTS WITH FIBROMYALGIA SYNDROME(2024-04-30) Sönmez S.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEAlthough the medical treatment and etiology of fibromyalgia are not fully understood, its effects on patients are considerable. Various symptoms such as chronic pain, fatigue, depression, sleep disturbances, and cognitive issues can significantly impact the quality of life of patients. In this context, the potential relationship between fibromyalgia and nutrition will be explored in this section. Studies examining the role of nutrient supplements in fibromyalgia suggest that dietary changes can reduce fibromyalgia symptoms and alleviate pain, implying potential positive effects. However, it has also been demonstrated that certain dietary components may increase the risk of fibromyalgia or exacerbate symptoms. Particularly, it has been noted that glutamate excitotoxin, a common food additive, may increase central pain sensitivity in individuals. Fibromyalgia is a common condition among rheumatic diseases and shares similarities with autoimmune thyroid diseases, especially hypothyroidism. Therefore, autoimmune thyroid disease, hypothyroidism, and Hashimoto\"s thyroiditis are also discussed in this work. Additionally, studies addressing the relationship between fibromyalgia diagnosis and treatment methods and thyroid diseases, one of the differential diagnoses, are compiled. In conclusion, advanced clinical research is needed to better understand the pathophysiological connection between fibromyalgia syndrome and thyroid diseases. Keywords: Fibromyalgia, Diagnosis and treatment, Nutrition, Autoimmune thyroiditisPublication Metadata only Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy(2024-03-01) Gençoğlu Katmerlikaya T.; Ersen B. C.; Dağ A.; Sancakli B.; Ozgen P. S. O.; Yalcin E. K.; Avci B.; DAĞ, AYDANPublication Metadata only HER YÖNÜYLE ANATOMİ 4. BASKI (baskıda)(İstanbul Tıp Kitabevi, 2024-05-01) Arifoğlu Y.; ARİFOĞLU, YASİNPublication Metadata only Endoscopic Ultrasound-Guided Pancreatic Duct Drainage(2024-01-01) Trieu J. A.; SEVEN G.; Baron T. H.; SEVEN, GÜLSERENPublication Metadata only Hair‑thread Tourniquet Syndrome: Two Case Reports and Review of the Literature(2024-04-01) EVİN N.; GASIMOV J.; DEMİR F. O.; ERBAYAT Y.; EVİN, NUH; GASIMOV, JOSHGUN; DEMİR, FATİH OSMAN; ERBAYAT, YUSUFHair‑thread tourniquet syndrome (HTTS) is an emergency phenomenon in which hair or thread tightly wraps around a protruding appendage of the body, resulting in pain, swelling, and rarely ischemia and amputation. While the toes, fingers, and external genitalia are the most affected areas, it can also impact other protruding parts of the body. Nevertheless, except for a few cases of skin tags and hemangioma, HTTS associated with a protruding skin mass is extremely rare in the literature. In this study, we present the management of two cases: One involving a pediatric patient with HTTS affecting the right fourth toe and the other involving a protruding pyogenic granuloma on the back of an adult patient.Publication Metadata only Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries(2024-01-01) Xu W.; Smith N.; Ting R.; Soh Q.; Saeed U.; Farrell M.; Wright D.; Li J.; Waraich A.; Gaborit L.; et al.; KALKAN, SENADBackground: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures. Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge. Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to sideeffects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (β coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and lowand middle-income countries, patient-reported outcomes did not. Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely.Publication Metadata only Treatment of Congenital Deformities of Cleft Foot and Syndactyly: A Case Report and Review of the Literature(2024-04-01) EVİN N.; VURAL Y.; KOÇ C.; UZER G.; EVİN, NUH; VURAL, YASİR; KOÇ, CAN; UZER, GÖKÇERCleft foot is a rare congenital anomaly characterized by a central conical defect and deficiency of the foot rays. Syndactyly is the fusion of the skin with or without the bone of adjacent digits, and it may be associated with syndrome‑related cleft foot. The aim of the treatment of cleft foot and syndactyly is to obtain a normal form and function by closing the cleft defect, obtaining symmetrical and cosmetic feet, allowing patients to wear normal shoes comfortably, and preventing collapse and angulation deformities of the toes. In this study, the treatment of congenital cleft foot and syndactyly coexistence is presented, and it is demonstrated that excess skin after soft‑tissue syndactylization of the cleft foot can be used to reconstruct syndactyly defects.Publication Metadata only GLUTEN-FREE NUTRITION APPLICATION IN HASHIMOTO’S THYROIDITIS(2024-05-20) Tayfur B. İ.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEThe immune system is responsible for protecting and defending our body under normal conditions and helps living things survive by neutralizing factors such as pathogens and infections that threaten the body. However, for some reasons, the body perceives itself as a threat and attacks itself, creating defects. The diseases that occur as a result of this situation are called autoimmune diseases, and if not intervened, they can lead the person from disability to death. Although the underlying causes are not fully understood, an autoimmune disease may also predispose to the formation of another autoimmune disease. However, as a result of research, it is thought that environmental factors together with genetic factors form a whole and cause these diseases. On the other hand, sometimes consumed foods or nutritional components may cause undesirable consequences for individuals. For example, studies have shown that the development of Hashimoto\"s thyroiditis (HT), an autoimmune disease, is supported by a gluten-containing diet. 70-80% genetic factors and 20-30% environmental factors play a role in the progression of this disease. While HT cases have increased rapidly in the last 30 years, the prevalence of the disease increases with age. HT, also known as chronic lymphocytic thyroiditis, is one of the most common autoimmune disorders of the thyroid gland. In the pathogenesis of the disease, there is a close connection with autoantibodies with lymphocytic infiltration along with B and T cells in the thyroid tissue. Chronic fatigue, irritability, unstable mood, as well as stomach, intestinal or cardiovascular problems may be observed in these patients. Additionally, a link has been identified between increased HT and primary thyroid lymphoma and papillary thyroid cancer. Although reported studies suggest that gluten exclusion may be beneficial for some individuals with HT, the diet is very limited, difficult to follow, and carries the risk of nutritional deficiency. In this review, the effect of gluten, a protein found in grains, on some common autoimmune diseases such as Hashimoto\"s thyroiditis has been examined in the light of current scientific publications. Answers were sought to the questions of whether removing gluten from the diet of individuals with autoimmune diseases would benefit the individual or alleviate their clinical symptoms.Keywords: Hashimoto\"s thyroiditis, Gluten-free diet, Autoimmune diseases, Immune systemPublication Metadata only Dr. Fatma Saada Emin Kaatcilar, One of the First Female Physicians of the Turkish Republic (1898-1982)(2023-09-01) YILDIRIM N.; YILDIRIM, NURANIn the early 20th century, since Istanbul University (Darulfunun) Faculty of Medicine did not accept female students, girls who wanted to study medicine began to go to Europe and America. First, Fatma SaadaEmin and Suad Mahmud Hanim from Izmir were sent to the SwitzerlandGeneva Medical Faculty, with their allocations and education expenses paid by the Aydin Province Special Administration (1915). The following year, the Ministry of Education sent Safiye Ali from Istanbul to the Faculty of Medicine of the University of Wurtzburg in Germany (1916). While they were continuing their education, as a result of the struggle initiated by the girls who wanted to become doctors in Istanbul, Istanbul University\"s Faculty of Medicine started to accept female students (1922). The province of Aydin sent Fatma Saada Emin 20 Ottoman liras every month and also paid 400 Francs as an annual education fee. The First World War ended in 1918, but due to the economic depression caused by the war conditions, this amount could not meet the young student\"s allocation needs. Their allocations were cut off when the Greeks occupied Izmir while the War of Independence was continuing. Fatma Saada Emin and Suad Mahmud Hanim, whose education was in jeopardy, applied to the Ottoman Consulate General in Geneva and expressed their grievances, and their situation was reported to Istanbul. The education expenses of both of them began to be paid from the Istanbul Province budget after 1921. Fatma Saada Emin completed her education, which was prolonged due to war conditions, in 1927 and received a diploma. After completing her specialization in internal medicine, she returned to Izmir. When she received her diploma equivalence certificate, she was appointed to the internal medicine clinic of Izmir Memleket Hospital (1930). Later, she opened a practice in Karsiyaka and started practicing freelance medicine (1932). In the 1943 general elections, she was elected as a member of parliament for the first term and entered the Turkish Grand National Assembly representing Manisa. (1943-1946). When her term as a member of parliament ended, she returned to Izmir and continued to work as a physician in Karsiyaka. Dr. Fatma Saada Emin Kaatcilar did not marry and devoted her life to her patients. She has an important place in the history of Turkish Medicine and women\"s studies, as she is one of the first two female students to go to Europe to study medicine, and in our political history, as the second elected female physician MP. However, no detailed research has been carried out on her so far. In this article, by sharing the information we have compiled from the sources we have access to, Dr. Fatma Saada Emin Kaatcilar is introduced, who served as a health guard for the people of Karsiyaka until her death, and who had the courage to go to a foreign country alone in the turbulent years of WW1, taking on a challenging education such as medicine, in a time when it was not tolerated for girls to even study.Publication Metadata only Sindirim Sistemindeki Mikroorganizmaların Obezite, Hipertansiyon Ve İnsülin Direncine Etkileri(Gece Kitaplığı, 2024-03-01) Şekerli Z.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEPublication Metadata only FODMAP ve Bazı Hastalıklarda FODMAP Diyet Uygulamaları(Özgür Yayınları, 2024-03-01) Semiz D.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEShort-chain carbohydrates, called FODMAPs, are fermentable, oligosaccharides, disaccharides, monosaccharides and polyols and are found in most foods. Some individuals may experience gastrointestinal symptoms such as gas, diarrhea, abdominal bloating and cramping when consuming foods containing FODMAPs. In addition, this significantly reduces the quality of life of these individuals and a low FODMAP diet is offered to control these symptoms. The Low FODMAP diet is based on restricting the intake of highly osmotic short-chain carbohydrates that are not slowly absorbed or digested in the human small intestine. On the other hand, Low FODMAP diet planning is implemented in three phases: FODMAP restriction, FODMAP reintroduction and then individualized selective FODMAP according to patients\" tolerance. The Low FODMAP diet has been applied in other functional gastrointestinal disorders, such as irritable bowel syndrome, non-celiac gluten sensitivity, inflammatory bowel diseases, and other functional gastrointestinal disorders. Thus, there is a reduction in symptoms and an increase in the quality of life of individuals with these conditions. However, FODMAP restriction in the diet of individuals also has disadvantages. Since most of the FODMAP components are prebiotic, it may lead to a decrease in fiber intake in the diet and may have negative effects on the intestinal microbiota. A health professional should be involved in the implementation of a low FODMAP diet and follow-up of symptoms. In particular, dietitians should determine the FODMAP components to which the patient is exposed on a daily basis, test food tolerance, check for dietary dependence, provide patient-specific dietary instructions, and ensure maximum dietary diversity by offering alternatives to food sources. This review aims to examine FODMAP carbohydrates, explain the low FODMAP diet, and provide an update on the evidence for the effects of a low FODMAP diet.Publication Metadata only Relationship between Kidney Diseases and Nutrition(2024-03-01) Şahin A.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEPublication Metadata only Fibromiyalji Sendromlu Hastalarda Tiroid Fonksiyonu Ve Beslenme(Efe Akademi Yayınları, 2024-03-01) Sönmez S.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEPublication Metadata only The prevalence and co-existence of geriatric syndromes in older patients with dementia compared to those without dementia(2024-12-01) SOYSAL P.; Smith L.; SOYSAL, PINARBackground: This study aims to compare frequency and coexistence of geriatric syndromes in older patients with dementia to those without dementia. Methods: 1392 patients admitted to geriatric outpatient clinics were evaluated. Evaluations for eleven geriatric syndromes including polypharmacy, malnutrition, fraility, sarcopenia, dysphagia, urinary incontinence, fear of falling, falls, insomnia, excessive daytime sleepiness, and orthostatic hypotension (OH) were carried out in consultation with the patient and the caregiver. Two groups with and without dementia were matched according to age and gender using the propensity score matching method. Results: A total of 738 patients, 369 with dementia and 369 without dementia were included, of whom 70.1% were female and the mean age was 80.5 ± 6.8. Polypharmacy, malnutrition, frailty, sarcopenia, dysphagia, fear of falling, and excessive daytime sleepiness were significantly higher in patients with dementia (p 0.05). The co-existence of 0, 1, 2, 3, 4 and ≥ 5 geriatric syndromes in the same patient was 4.3%, 10.2%, 11.8%, 16.8%, 13.4% and 43.7% in non-dementia patients, respectively; 2.4%, 7.2%, 9.6%, 8.3%, 10.4% and 62.1% in those with dementia, respectively (p < 0.05). Conclusion: The presence and co-existence of geriatric syndromes is common in patients with dementia. These geriatric syndromes should be examined by clinicians and healthcare professionals who work with the demented population, so that more successful management of dementia patients may be achieved.Publication Metadata only Treatment outcomes and prognostic factors in patients with driver mutant non-small cell lung cancer and de novo brain metastases(2024-12-01) Kahraman S.; Karakaya S.; Kaplan M. A.; SEZGİN GÖKSU S.; Ozturk A.; Isleyen Z. S.; HAMDARD J.; Yildirim S.; Dogan T.; Isik S.; et al.; TÜRK, HACI MEHMETCentral nervous system (CNS) metastases can be seen at a rate of 30% in advanced stages for patients with non-small cell lung cancer (NSCLC). Growing evidence indicates the predictive roles of driver gene mutations in the development of brain metastases (BM) in recent years, meaning that oncogene-driven NSCLC have a high incidence of BM at diagnosis. Today, 3rd generation targeted drugs with high intracranial efficacy, which can cross the blood–brain barrier, have made a positive contribution to survival for these patients with an increased propensity to BM. It is important to update the clinical and pathological factors reflected in the survival with real-life data. A multi-center, retrospective database of 306 patients diagnosed with driver mutant NSCLC and initially presented with BM between between November 2008 and September 2022 were analyzed. The median progression-free survival (mPFS) was 12.25 months (95% CI, 10–14.5). While 254 of the patients received tyrosine kinase inhibitor (TKI), 51 patients received chemotherapy as first line treatment. The median intracranial PFS (iPFS) was 18.5 months (95% CI, 14.8–22.2). The median overall survival (OS) was 29 months (95% CI, 25.2–33.0). It was found that having 3 or less BM and absence of extracranial metastases were significantly associated with better mOS and iPFS. The relationship between the size of BM and survival was found to be non-significant. Among patients with advanced NSCLC with de novo BM carrying a driver mutation, long-term progression-free and overall survival can be achieved with the advent of targeted agents with high CNS efficacy with more conservative and localized radiotherapy modalities.Publication Metadata only Examination of the Relationship Between Sella Turcica and Impacted Maxillary Canine Teeth: A Retrospective Study(2024-01-01) Açıkgöz G.; SARICA İ.; Bilge N. H.; Akgül H. M.; SARICA, İRFANObjectives: In the present study, we aimed to compare the morphological shape and linear dimensions of the sella turcica (ST) between individuals with and without impacted maxillary canines (IMC). Materials and Methods: Cone-beam computed tomography scans of 120 individuals with IMC (study group) were obtained, retrospectively. This study group was divided into three subgroups: group I (n=40), right IMC; group II (n=44), left IMC; and group III (n=36), bilateral IMC. A control group of 40 individuals without IMC were included in this study from the same archive. The study group was divided into three subgroups: group I (n=40), right IMC; group II (n=44), left IMC; and group III (n=36), bilateral IMC. The shape and the linear dimensions of the ST were evaluated in all groups. Data were analyzed using an independent sample t-test and the chi-square test. The significance level was assigned as p<0.05. Results: The linear dimensions ‒length, depth, and diameter‒ of the ST in the control group were significantly different from those in group I (p=0.050, p=0.001, and p=0.018, respectively), group II (p=0.040, p=0.048, and p=0.006, respectively), and group III (p=0.014, p=0.039, and p=0.007, respectively). In addition, there were no statistically significant associations among ST types in the control and study groups. Conclusions: The length, depth, and diameter of the ST were greater in the control group than in the individuals with unilateral or bilateral IMC. Also, no relationship was found between the morphological shapes of the ST in individuals with and without IMC.Publication Metadata only Beneficial effects of adipose-derived stromal vascular fraction on testicular injury caused by busulfan(2024-03-01) Hekimoğlu E. R.; Eşrefoğlu M.; Karakaya F. B.; Elibol B.; Dedeakayoğulları H.; Pasin Ö.; HEKİMOĞLU, EMİNE RÜMEYSA; EŞREFOĞLU, MUKADDES; KARAKAYA, FATMA BEDİA; PASİN, ÖZGEPublication Metadata only Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: known knowns and known unknowns(2024-04-01) Levin A.; Ahmed S. B.; Carrero J. J.; Foster B.; Francis A.; Hall R. K.; Herrington W. G.; Hill G.; Inker L. A.; KAZANCIOĞLU R.; et al.; KAZANCIOĞLU, RÜMEYZAThe Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD) updates the KDIGO 2012 guideline and has been developed with patient partners, clinicians, and researchers around the world, using robust methodology. This update, based on a substantially broader base of evidence than has previously been available, reflects an exciting time in nephrology. New therapies and strategies have been tested in large and diverse populations that help to inform care; however, this guideline is not intended for people receiving dialysis nor those who have a kidney transplant. The document is sensitive to international considerations, CKD across the lifespan, and discusses special considerations in implementation. The scope includes chapters dedicated to the evaluation and risk assessment of people with CKD, management to delay CKD progression and its complications, medication management and drug stewardship in CKD, and optimal models of CKD care. Treatment approaches and actionable guideline recommendations are based on systematic reviews of relevant studies and appraisal of the quality of the evidence and the strength of recommendations which followed the \"Grading of Recommendations Assessment, Development, and Evaluation\" (GRADE) approach. The limitations of the evidence are discussed. The guideline also provides practice points, which serve to direct clinical care or activities for which a systematic review was not conducted, and it includes useful infographics and describes an important research agenda for the future. It targets a broad audience of people with CKD and their healthcare, while being mindful of implications for policy and payment.Publication Metadata only Identification of suitable reference genes for RT-qPCR studies in human parathyroid tissue glandular cells.(2024-06-20) Goncu B. S.; GÖNCÜ, BEYZA SERVETIdentifying a proper reference gene allows us to understand fundamental changes in many biological processes. Normalization during gene expression analyses is essential for every tissue/cell type, including parathyroid tissue glandular cells. The quantitative method of gene expression analyses via qRT-PCR provides an accurate examination of every target gene. There are limited reports to present commonly used reference genes in human parathyroid tissues rather than for glandular cell types. This study aims to determine and compare the most stable to least stable genes for parathyroid tissue cells. 43 human parathyroid tissue and glandular cells obtained from primary and secondary hyperparathyroidism patients were isolated enzymatically by removing extracellular matrix components. After extraction of the total RNA, cDNA synthesis was performed, then qRT-PCR evaluated 14 candidate reference genes. Stability was determined by RefFinder software (Delta ct, BestKeeper, Genorm, and NormFinder algorithms), and the outcome was evaluated for five groups. Even if assessed with different groups, the most stable genes were RPLP0 and GAPDH, while the CLTC and RNA 18S were the least stable. We confirmed the comprehensive ranking of the most stable three genes alone with the NormFinder algorithm to understand intergroup variation and found that RPLP0>GAPDH>PGK1. Lastly, relative target gene (GCM2) expression comparisons revealed similar expression patterns for the most stable reference genes. The most stable reference gene is recommended for the stages where stability is evaluated using the results of four different approaches using RefFinder. We aspire for this study to assist future research to conduct thorough assessments of appropriate reference genes before engaging in gene expression analyses for parathyroid tissue