Publication: The effect of systemically administrated zoledronic acid on the osseointegration of dental implants
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Date
2012-11-01
Authors
DOLANMAZ, DOĞAN
Authors
Ayan, M.
Dolanmaz, DOĞAN
Mihmanli, A.
Ayan, A.
KÜRKÇÜ, MEHMET
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Abstract
OBJECTIVE: The aim of conducting this study was to
evaluate the effect of zoledronic acid (ZA) on the new
bone formation (NBF) after the insertion of a titanium
dental implant, which is very popular treatment in
dentistry.
STUDY DESIGN: Twelve New Zealand white rabbits
were used in this study. The rabbits were divided in two
groups. ZA was systemically administered to the study
group. Titanium implants were placed to the left and
right tibias of the rabbits.
RESULTS: The data from the ZA group revealed a statistically significant increase in the bone mineral content
and the bone mineral density. A non-decalcified histomorphometric examination conducted on the study
group revealed a significant increase of NBF and boneimplant contact (BIC) at 2 and 4 weeks.
CONCLUSION: A single dose of systemic ZA administration increases the rate of NBF and augments the
quality of the bone.
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Keywords
Dental implants
Citation
Ayan M., Dolanmaz D., Mihmanli A., Ayan A., KÜRKÇÜ M., -The effect of systemically administrated zoledronic acid on the osseointegration of dental implants-, ORAL DISEASES, cilt.18, ss.802-808, 2012