Sağlık Hizmetleri Meslek Yüksekokulu

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  • PublicationMetadata only
    The role of the clinical pharmacist in patient education and monitoring of patients under warfarin treatment
    (2019-01-01) İZZETTİN, FİKRET VEHBİ; Celik, Sevda; Acar, Rezzan Deniz; TEZCAN, SONGÜL; Aksoy, Nilay; BEKTAY, MUHAMMED YUNUS; SANCAR, MESUT; İZZETTİN, FIKRET VEHBI
    This study was carried out on patients who were under anticoagulation treatment with warfarin, at the outpatient cardiology clinic. The aim was to determine the effectiveness of pharmacist consultation, education, and intervention on each patient-s therapeutic results. A cross-sectional randomized trial has been done. Twenty-five patients were included in the study. The Oral Anticoagulation Knowledge (OAK) Test, Short Form-36 (SF-36) and Duke Anticoagulation Satisfaction Scale (DASS) were applied. Patients resumed their routine anticoagulation treatment and INR and complications were recorded during the study. Additionally, patients received patient education, consultation on lifestyle and anticoagulant usage issues from a pharmacist. The same tests were applied again to the patients on the 90th day of the study and the results were compared with the initial test. Maintenance of INR within the target range and complication rates were compared before and after the intervention. Pre-test and post-test results of the patients revealed statistically significant improvements on the physical and mental score components of the SF-36 (p = 0.001; p = 0.001), OAK test scores (p <= 0.001) and the (negative) -limitations- and -burdens- and -positive effects- components of the DASS (p = 0.005; p < 0.001; p = 0.001). The successful maintenance of INR within target range was significantly higher (p = 0.027). The positive effects of pharmacist consultation and education on therapeutic results were demonstrated.
  • PublicationMetadata only
    Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer-s disease
    (2019-10-01) Elibol, Birsen; Şahbaz, Çiğdem Dilek; Beker, Merve; Terzioğlu, Şule; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; BEKER, MERVE; ŞAHBAZ, ÇIĞDEM DILEK
    OBJECTIVES: Alzheimer-s disease (AD) is a severe neurodegenerative disease with presentation of the neuronal death, memory loss and cognitive decline. The relationship between neuroinflammation and AD has been well documented. However, the options of anti-inflammatory treatment are very limited in patients with AD. Previous studies showed that flavonoids might be an effective treatment and thymoquinone (TQ), an aromatic hydrocarbon found in Nigella sativa suggested as a candidate molecule due to having strong anti-inflammatory effects. Our study aimed to investigate the effects of TQ on neuroinflammation and neuroprotection in A beta((1-42)) infused rat model of AD.
  • PublicationMetadata only
    Regression of Serous Macular Detachment After Intravitreal Dexamethasone Implant in Patients with Diabetic Macular Edema.
    (2019-10-24) Ozdemir, MH; Ekinci, C; Kirik, F; Koytak, A; ÖZDEMİR, MEHMET HAKAN; ELBAY, AHMET; KIRIK, FURKAN; EKİNCİ, CANSU; KOYTAK, İBRAHİM ARİF
  • PublicationMetadata only
    Patterns of Altered Corneal Sensation in Patients With Chronic Migraine.
    (2018-11-01) Aykut, V; Elbay, AHMET; Esen, F; Kocaman, G; Savran, Elibol; Oguz, H; ELBAY, AHMET
  • PublicationMetadata only
    Serum SUR1 and TRPM4 in patients with subarachnoid hemorrhage.
    (2019-11-09) Uysal, O; Yurtsever, I; Abdallah, A; Dundar, TT; Guler, Eray Metin; Ozer, OF; DÜNDAR, TOLGA TURAN; YURTSEVER, İSMAİL; GÜLER, ERAY METİN; ÖZER, ÖMER FARUK; UYSAL, ÖMER
    Neuroinflammation plays an important role in neuronal injury after aneurysmal subarachnoid hemorrhage (aSAH). Sulfonylurea receptor 1 (SUR1) and transient receptor potential cation channel subfamily M member 4 (TRPM4) receptors play an important role in the pathogenesis of several neural injuries, such as neural edema, spinal cord damage, stroke, and neuronal damage in aSAH. This study aimed to investigate the relationship of serum SUR1 and TRPM4 levels with the neurological status within the first 15 days after aSAH. In this prospective study, blood samples were collected from 44 consecutive patients on the 1st, 4th, and 14th days after aSAH. Serum SUR1 and TRPM4 levels were measured using an enzyme-linked immunosorbent assay kit. Glasgow coma scale and World Federation of Neurosurgical Societies (WFNS) scores upon presentation and Glasgow outcome scale (GOS) score on the 14th day were recorded. Serum SUR1 and TRPM4 levels on the 1st, 4th, and 14th days were significantly higher in patients with aSAH than in normal individuals. This increase in the levels varied among the 1st, 4th, and 14th days. On the first day, a correlation was observed between serum SUR1, but not TRPM4, levels and the WFNS score. Moreover, on the 14th day, an association of serum SUR1 and TRPM4 levels with the GOS score was noted. Serum SUR1 and TRPM4 levels were significantly upregulated in the peripheral blood samples. Further study is warranted to establish the utility of SUR1 and TRPM4 as biomarkers in patients with aSAH.
  • PublicationOpen Access
    Quercus pyrenaica Honeydew Honey With High Phenolic Contents Cause DNA Damage, Apoptosis, and Cell Death Through Generation of Reactive Oxygen Species in Gastric Adenocarcinoma Cells
    (2019-09-01) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; GÜLER, Eray Metin; BULUT, HURİ; KÖKTAŞOĞLU, FATMANUR; Goeren, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN
    Many studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains Quercus pyrenaica honeydew honey (QPHH-IM) having the highest phenolic and antioxidant content and Canakkale multifloral honey (MFH-C) with the lowest phenolic and antioxidant content. Levels of 11 different phenolic compounds in QPHH-IM and MFH-C samples were determined by LC-MS/MS. AGS cells were incubated with different concentrations of QPHH-IM and MFH-C for 24 hours, then the cell viability, DNA damage, apoptosis, and generation of ROS were determined. We found that QPHH-IM had more cytotoxic, genotoxic, and apoptotic effects than that of MFH-C. We think that these effects are probably related to pro-oxidant activities due to the high phenolic contents present. Therefore, further research on high-phenolic honey may contribute to the future development of cancer therapeutics.
  • PublicationMetadata only
    Retinal ven kök tıkanıklığına bağlı gelisen makula ödemi tedavisinde intravitreal triamsinolon asetonid ve ranibizumabın karşılaştırılması
    (2013-11-10) ARTUNAY, OZGUR; SENGUL, ALPER; KOYTAK, İBRAHİM ARİF; AYINTAP, EMRE; UMURHAN AKKAN, JÜLİDE CANAN; ALTINISIK, MUHAMMED; TOKLU, ENES; TUNCER, KEMAL; KOYTAK, İBRAHİM ARİF; UMURHAN AKKAN, JÜLİDE CANAN
  • PublicationOpen Access
    Ileocecal Intussusception due to a Lipoma in an Adult.
    (2012-01-01) Bilgin, MEHMET; Toprak, HÜSEYİN; AHMAD, ISSAM CHEIKH; YARDIMCI, ERKAN; KOCAKOÇ, ERCAN; BİLGİN, MEHMET; TOPRAK, HÜSEYİN; YARDIMCI, ERKAN
    While intestinal tumors are rare, small intestinal lipomas are even more uncommon benign neoplasms. They are usually asymptomatic, but lipomas larger than 2 cm may become symptomatic due to obstruction, bleeding, or intussusception. In this paper, US and CT findings of a lipoma located in the terminal ileum and causing ileocecal intussusception were discussed. We report a case of small bowel lipoma that became symptomatic due to intermittent obstruction episodes and ileocecal intussuception. If the diagnosis of intestinal lipoma had been made absolutely as in our case, they should be removed surgically in elective conditions.
  • PublicationMetadata only
    KIKIRDAK(TUSYAD EĞİTİCİ KİTAP SERİSİ)
    (2016-01-01) UZER, GÖKÇER; YILDIZ, FATİH; ELMALI, NURZAT; UZER, GÖKÇER; YILDIZ, FATİH
  • PublicationMetadata only
    ARTROSKOPİK CERRAHİ GÜNCEL BİLGİLER VE TEKNİKLER (TUSYAD EĞİTİCİ KİTAP SERİSİ)
    (2016-01-01) TUNCAY, İBRAHİM; UZER, GÖKÇER; TUNCAY, İBRAHİM; UZER, GÖKÇER
  • PublicationMetadata only
    Glokom şüphesi olan miyopik olduda atipik peripapiller retinoskizis
    (2015-11-08) SOYLU, UGUR; UMURHAN AKKAN, JÜLİDE CANAN; OZDEMIR, HAKAN; UMURHAN AKKAN, JÜLİDE CANAN
  • PublicationMetadata only
    Repeated bevacizumab injections versus mitomycin C in rotational conjunctival flap for prevention of pterygium recurrence
    (2014-04-01) ÖZSÜTÇÜ, Mustafa; AYINTAP, Emre; Akkan, JÜLİDE CANAN; KOYTAK, Arif; ARAS, Cengiz; UMURHAN AKKAN, JÜLİDE CANAN; KOYTAK, İBRAHİM ARİF
    Aims: To evaluate the efficacy of repeated bevacizumab injection in rotational conjunctival flap surgery versus rotational conjunctival flap with adjunctive mitomycin C (MMC) or rotational conjunctival flap alone. Materials and methods: Ninety eyes of 90 patients who underwent primary pterygium surgery with rotational flap were evaluated. Patients were randomly assigned to undergo conjunctival rotational flap alone (Group A) or conjunctival rotational flap with either 0.02% MMC application (Group B) or adjunctive subconjunctival 2.5 mg/0.1 ml bevacizumab injection (Group C). Each group consisted of 30 eyes. Recurrence rates at 9 months were evaluated. Results: There were no statistically significant differences in mean size of the pterygium across the limbus in terms of length (P > 0.5). The recurrence rates at 9 months were 26.6% (n = 8) in Group A, 13.3% (n = 4) in Group B, and 10% (n = 3) in Group C. The recurrence rates in Group B and C were significantly lower than in Group A (P = 0.1806). The recurrence rates were similar in Group B and C (P > 0.05). Conclusions: Subconjunctival bevacizumab injection may decrease the recurrence rate of primary pterygium surgery with rotational conjunctival flap. Further studies with a larger population and longer follow-up period are needed to supplement this study.
  • PublicationMetadata only
    Bezmialem Vakıf Üniversitesi Sağlık Hizmetleri Meslek Yüksekokulu Öğrenci ve Eğitici Profili
    (2016-05-14) BAŞARANOĞLU, GÖKÇEN; ÜYÜKLÜ, MEHMET; YÜKSEL, HÜSEYİN EMRE; ÇAKIR, Muhammet Sacit; BAŞARANOĞLU, GÖKÇEN; ÜYÜKLÜ, MEHMET; YÜKSEL, HÜSEYIN EMRE
  • PublicationMetadata only
    Retina ven tıkanıklığına bağlı anti VEGF dirençli macula ödemi olgularında intravitreal deksametazon implant etkinligi
    (2015-11-08) TOKLU, ENES; KOYTAK, İBRAHİM ARİF; UMURHAN AKKAN, JÜLİDE CANAN; HIDAYETOV, FUAT; ÖZDEMIR, MEHMET HAKAN; KOYTAK, İBRAHİM ARİF; UMURHAN AKKAN, JÜLİDE CANAN
  • PublicationMetadata only
    Dose-dependent proliferative and cytotoxic effects of melatonin on human epidermoid carcinoma and normal skin fibroblast cells
    (2018-05-01) KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KARATAŞ, Ersin; CAGLAR, Hifa; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; BULUT, HURI
  • PublicationMetadata only
    Idiopatik orbital inflamatuar hastalığı olan ve uzun sure tedavisiz kalmış bir olgu
    (2014-11-09) AYINTAP, EMRE; UMURHAN AKKAN, JÜLİDE CANAN; KOYTAK, İBRAHİM ARİF; ARTUNAY, OZGUR; ALTINISIK, MUHAMMED; SEZER, TAHA; TUNCER, KEMAL; UMURHAN AKKAN, JÜLİDE CANAN; KOYTAK, İBRAHİM ARİF; SEZER, TAHA
  • PublicationMetadata only
    Anti-inflammatory and antioxidative properties of honey bee venom on Freund’xxs Complete Adjuvant-induced arthritis model in rats
    (2019-04-01) KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KALELİ, SÜLEYMAN; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN
    The aim of this study was to assess anti-inflammatory, anti-oxidant, anti-genotoxic and immunomodulatory effects of honey bee venom (HBV) on adjuvant-induced arthritis in rats. Thirty-five rats were equally divided into a negative control (NC), a positive control (PC) and low, moderate and high doses (2, 4 and 20 mg/kg, respectively) of HBV treatment groups. Freund-s Complete Adjuvant (FCA) was given to the rats to form arthritis. The treatment groups were treated with HBV for 3 consecutive weeks. After the treatment, plasma IL-1 beta, IL-6, TNF-alpha, IFN-gamma and TGF-beta 1, total oxidant status (TOS), total antioxidant status (TAS) and myeloperoxidase (MPO) activities and mononuclear leukocyte (MNL) DNA damage levels were measured. Oxidative stress index (OSI) was calculated. IL-beta, IL-6, TNF-alpha, TGF-beta 1, IFN-gamma, TOS, OSI, DNA damage levels and MPO activities were significantly higher and TAS levels were lower in the PC group than the NC. After low-doses of HBV treatment IL-1 beta, IL-6, TNF-alpha, TGF-beta 1, TOS, OSI, MPO and MNL-DNA damage levels significantly decreased according to the PC, while IFN-gamma and TAS levels increased. The differences in moderate and high-dose HBV treatment groups were not as significant as low HBV doses. Low-doses of HBV has been shown to treat RA with anti-inflammatory and antioxidant effects, by preventing DNA damage. However, these effects have not been observed as strong at higher doses of HBV. In summary, HBV may be an effective option to ameliorate RA, but the optimization of the therapeutic dose has a crucial role.
  • PublicationMetadata only
    ÇOCUKLUK ÇAĞI KRONIK IDIYOPATIK ÜRTIKERINDE PLAZMA TIYOL DENGESI VE HASTALIK AĞIRLIĞI ILE ILIŞKISI
    (2018-04-20) DİLEK, FATİH; ÖZÇEKER, DENİZ; ÖZKAYA, EMİN; GÜLER, ERAY METİN; TAMAY, ZEYNEP ÜLKER; KOÇYİĞİT, ABDURRAHİM; GÜLER, NERMİN; ÖZKAYA, EMİN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM
  • PublicationOpen Access
    Investigation of cytotoxic, genotoxic, and apoptotic effects of curcumin on glioma cells
    (2019-03-01) SEYİTHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS; kitiş, serkan; GÜLER, ERAY METİN; DÜNDAR, TOLGA; GÜNDAĞ PAPAKER, MELİHA; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; DÜNDAR, TOLGA TURAN; GUNDAG, MELİHA
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    60 YAŞ ALTI BAYAN MEDİAL EKLEM OSTEOARTRİTİ OLAN HASTALARDA UNİKOMPARTMANTAL DİZ PROTEZİ VE YÜKSEK TİBİAL OSTEOTOMİNİN KLİNİK VE FONKSİYONEL SONUÇLARININ KARŞILAŞTIRILMASI
    (2014-11-16) UZER, GÖKÇER; YILDIZ, FATİH; ELMADAĞ, NUH MEHMET; KARA, DENİZ; TUNCAY, İBRAHİM; UZER, GÖKÇER; YILDIZ, FATİH; ELMADAĞ, NUH MEHMET; TUNCAY, İBRAHİM