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Publication Metadata only Temel Mitokondriyal Tıp(2019-10-01) Bektay, Muhammed Yunus; BEKTAY, MUHAMMED YUNUSBilimsel ve teknolojik gelişime rağmen toplumdaki hastalık yükümüzün yaklaşık yüzde 90’ını Multifaktoriyal Kronik- Kompleks Hastalıklar oluşturmaktadır. Kronik Kompleks hastalıklarda ortak etyoloji Oksidatif Stres olup, patogenezi hücre düzeyinde başlatan ve uzun süre gizli/latent hasara neden olan ve son aşamalarında klinik tablonun ortaya çıkmasıyla ancak anlaşılabilecek hücresel düzeyde bir zedeleyicidir.Oksidatif stres hasarı Mitokondriyal Disfonksiyon’a yol açarak organizmada enerji (ATP) sentezini azaltmakta ve ardından değişen fonksiyonel, yapısal ve epigenetik Denge ve Adaptasyonun Bozulması’na neden olarak, iç içe geçmiş karmaşık klinik tablolar nedeniyle tanı ve tedaviyi güçleştirmektedir.Neredeyse tüm zedeleyiciler serbest radikal üretimini arttırarak, hücre zarı, mitokondri, endoplazmik retikulum, golgi cisimciği dahil tüm membranöz yapıların hasarlanmasına ve bir dizi fonksiyon bozukluğuna neden olurlar. Yaklaşmakta olan, Kronik Hastalıklar Tsunamisi diyebileceğimiz, bu tür hastalıklarla kalıcı şekilde baş edebilmek için Etyo-patogenez, Fizyopatoloji ve Biyokimya bilgisinin tıbbi tanı ve tedavide kullanılması Kişiye Özel Bütüncül Tıp Yaklaşımının Temelidir.Bunu yapabilmenin ilk basamaklarından biri de Mitokondriyal Tıp bilgisine sahip olmaktır. Bu amaçla sağlık profesyonelleri için Türkçeye tercümesini kazandırdığımız Temel Mitokondriyal Tıp kitabının camiamıza hayırlı olmasını diliyoruz.Publication Metadata only Comparison of Different Decision Support Software Programs in Perspective of Potential Drug-Drug Interactions In Oncology Clinic(2019-10-23) Bektay, Muhammed Yunus; Şeker, Zehra; Eke, Hatice Kübra; Türk, Hacı Mehmet; İzzettin, Fikret VehbiBackground and Objective: Cancer treatment is one the most compelling situation for healthcare providers. The situation itself already complicated enough. In addition, cancer treatment requires multiple medication usage simultaneously. Drug-drug interactions (DDI) compose 20-30% of adverse effects. Drug-drug interactions are responsible 4% of mortality in oncology. Cancer patients are more prone to experience drug-drug interactions, because of taking multiple medications with anticancer agents to reduce or prevent the side effects that are caused by chemotherapeutic agents.Since the clinical pharmacists have a key role to prevent DDIs and to enhance the patients’ quality of life, a multidisciplinary approach is an important necessity in cancer care.Setting and Method: Cross-sectional observational study was conducted through interviews with 133 patients. In our study we would like to evaluate DDIs of patient who applied Oncology clinic of Bezmialem Vakif University Istanbul Turkey. This study has been approved by noninvasive Clinical Research Ethics Committee of Bezmialem Vakif University with decision number of 21/286 on 21.112017. Drug-drug interactions were evaluated using three sources: Lexicomp®, Medscape® and Micromedex®. Interaction levels have been taking into consideration were serious-use alternative and monitor closely for Medscape®, Serious-Use Alternative and Major Micromedex® and Category X and D for Lexicomp®.Main outcome measures: Evaluation of DDIs in perspective of number and comparison between different clinical decision support systems.Results: 244 different medicine prescribed 1712 times to 133 patients. According to our results number of DDIs were 265-1472 (1,99-11,07 DDI/patient) for Medscape®, 38-1006 (0,29-7,56 DDI/patient) for Micromedex and for Lexicomp® were 86-532 (1,99-4,00 DDI/patient).Conclusion: This study revealed that DDIs is common problem among oncology patients in hospital settings. When pharmacist making a decision using various software and decision support systems with different level of evidences. This study showed us that trusting one software completely could lead clinician to failure. On the other hand, patients with comorbidities, renal impairment and polypharmacy are more prone to have more DRPs.Publication Metadata only Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3 beta-pentacosanoate for the symptomatic treatment of multiple sclerosis(2019-07-01) DAĞ, AYDAN; Sen, A.; ŞENOL, HALİL; Kale, E.; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Metadata only Nükleer Faktör Kappa-B İnhibisyon Etkili Ursan Türevi Triterpenlerin Bilgisayar Destekli Tasarımı, Sentezi ve Bazı Biyolojik Etkinliklerinin Araştırılması(2019-10-19) Şenol, Halil; ŞENOL, HALILPublication Metadata only Cardiotoxicity Induced by Tyrosine Kinase Inhibitors(2019-10-16) Günaydın, Ayşenur; Boran, Tuğçe; Jannuzzı, Ayşe Tarbın; Alpertunga, Büket; GÜNAYDIN AKYILDIZ, AYŞENURPublication Metadata only Practical and theoretical considerations for the determination of delta C-13(VPDB) values of methylmercury in the environment(2019-07-15) Dunn, Philip J. H.; Bilsel, Mine; Simsek, Adnan; Goren, AHMET CEYHAN; Tunc, Murat; Ogrinc, Nives; Horvat, Milena; Goenaga-Infante, Heidi; GÖREN, AHMET CEYHANRationale Analytical methods that can identify the source and fate of mercury and organomercury compounds are likely to be useful tools to investigate mercury in the environment. Carbon isotope ratio analysis of methylmercury (MeHg) together with mercury isotope ratios may offer a robust tool to study environmental cycling of organomercury compounds within fish tissues and other matrices. Methods MeHg carbon isotope ratios were determined by gas chromatography/combustion-isotope ratio mass spectrometry (GC/C-IRMS) either directly or following derivatization using sodium tetraethylborate. The effects of a normalization protocol and of derivatization on the measurement uncertainty of the methylmercury delta C-13(VPDB) values were investigated. Results GC/C-IRMS analysis resulted in a delta C-13(VPDB) value for an in-house MeHg reference material of delta C-13(VPDB) = -68.3 +/- 7.7 parts per thousand (combined standard uncertainty, k = 1). This agreed very well with the value obtained by offline flow-injection analysis/chemical oxidation/isotope ratio mass spectrometry of delta C-13(VPDB) = -68.85 +/- 0.17 parts per thousand (combined standard uncertainty, k = 1) although the uncertainty was substantially larger. The minimum amount of MeHg required for analysis was determined to be 20 mu g. Conclusions While the delta C-13(VPDB) values of MeHg can be obtained by GC/C-IRMS methods with or without derivatization, the low abundance of MeHg precludes such analyses in fish tissues unless there is substantial MeHg contamination. Environmental samples with sufficient MeHg pollution can be studied using these methods provided that the MeHg can be quantitatively extracted. The more general findings from this study regarding derivatization protocol implementation within an autosampler vial as well as measurement uncertainty associated with derivatization, normalization to reporting scales and integration are applicable to other GC/C-IRMS-based measurements.Publication Metadata only Sage (Salvia pilifera): determination of its polyphenol contents, anticholinergic, antidiabetic and antioxidant activities(2019-09-01) GÜLÇİN, İlhami; Tel, Ahmet Zafer; GÖREN, AHMET CEYHAN; Taslimi, Parham; Alwasel, Saleh H.; GÖREN, AHMET CEYHANIn this work, we determined for the first time the Salvia pilifera Montbret & Aucher ex Bentham as an important source for natural products with antioxidant and antidiabetic potentials. In this context, methanol (MESP) and water (WESP) extracts were prepared from aerial parts of S. pilifera. Also, it was evaluated for antioxidant profile by eight distinguishes bioanalytical methods and inhibition effects against enzymes linked to different diseases, namely butyrylcholinesterase (BChE), acetylcholinesterase (AChE), alpha-glycosidase and alpha-amylase. Also, the polyphenolic compositions of MESP and WESP were evaluated by high performance liquid chromatography and tandem mass spectrometry (LC-MS/MS). Fourteen phenolics were identified in the evaporated MESP and thirteen phenolic compounds were identified in the lyophilized WESP. Also, we performed the antioxidant properties of both extracts. In order to estimate the capacity of MESP and WESP to act as antioxidants, 1,1-diphenyl-2-picryl-hydrazyl radicals (DPPH center dot), 2,2 --azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radicals (ABTS(center dot+)) and N,N-dimethyl-p-phenylenediamine radicals (DMPD center dot+), scavenging activities, ferric ions (Fe3+), Fe3+-TPTZ and cupric ions (Cu2+) reducing assays were studied. MESP and WESP were found as potent effective DPPH center dot (IC50: 7.05 and 8.56 mu g/mL), ABTS(center dot+) (IC50: 3.52 and 4.76 mu g/mL) and DMPD center dot+ (IC50: 28.92 and 30.95 mu g/mL) scavenging effects. On the other hand, MESP and WESP showed the potent inhibition effects against AChE (IC50: 94.93 and 138.61 mu g/mL), BChE (IC50: 60.05 and 99.13 mu g/mL), alpha-glycosidase (IC50: 23.28 and 36.47 mu g/mL) and alpha-amylase (IC50: 46.21 and 97.67 mu g/mL) enzymes. This study will be an innovative and guider for further studies for antioxidant properties for industrial or medicinal plants.Publication Metadata only Temel Mitokondriyal Tıp(2019-09-01) Gören, Ahmet Ceyhan; GÖREN, AHMET CEYHANPublication Open Access Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS(2019-01-01) GÜLÇİN, İlhami; Kaya, Ruya; GÖREN, AHMET CEYHAN; Akincioglu, Hulya; Topal, Meryem; Bingol, Zeynebe; Cakmak, Kader Cetin; Sarikaya, Sevim B. Ozturk; DURMAZ, LOKMAN; Alwasel, Saleh; GÖREN, AHMET CEYHANEthanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. Their inhibitory effects were tested against some enzymes including acetylcholinesterase, butyrylcholinesterase, alpha-glycosidase and alpha-amylase, which linked to different diseases. Additionally, the antioxidant properties were determined and polyphenolic compositions of the both extracts were evaluated by LC-MS/MS analysis. According to the LC-MS/MS experiments, thirteen compounds were found in WEC and EEC. Also, p-hydroxybenzoic acid (321.1 mg/kg extract), p-coumaric acid (291.4 mg/kg extract), and pyrogallol (142.4 mg/kg extract) were found to be the most abundant ingredients in the WEC. On the other hand, pyrogallol (264.3 mg/kg extract), ferulic acid (224.7 mg/kg extract) and p-coumaric acid (170.2 mg/kg extract) were found as the most plentiful chemicals in the EEC. For the estimation of the antioxidant capacities of the both extracts (WEC and EEC), DPPH center dot and ABTS(center dot+) scavenging activities, as well as Fe3+-Fe2+, and Cu2+-Cu+ reducing assays were studied. The IC50 values of the WEC and EEC indicated that they were potent effective DPPH center dot (21. 25 and 15.71 mu g/mL) and ABTS(center dot+) (6.52 and 5.79 mu g/mL) scavengers, as well as AChE (221.33 and 110.26 mu g/mL), BChE (461.69 and 94.93 mu g/mL), alpha-glycosidase (206.86 and 220.00 mu g/mL) and alpha-amylase (189.86 and 200.86 mu g/mL) inhibitors. As a conclusion, both EEC and WEC had rich phenolic contents and demonstrated effective anticholinergic, antidiabetic and antioxidant effects.Publication Metadata only Microwave absorption properties of MFe2O4 (M= Fe, Co and Mn) nanoparticles and their composites with polythiophene (PTh)(2015-05-03) UNVER, IBRAHIM SAIM; GÖKÇE, SERDAR; KAVAS, H.; DURMUŞ, ZEHRA; AKTAS, BEKIRPublication Open Access Cytotoxic, genotoxic and apoptotic effects of naringenin-oxime relative to naringenin on normal and cancer cell lines(2016-10-01) KOÇYİĞİT, ABDÜRRAHİM; Koyuncu, Ismail; Dikilitas, Murat; BAHADORİ, FATEMEH; Turkkan, Baki; KOÇYİĞİT, ABDÜRRAHİM; BAHADORİ, FATEMEHPublication Metadata only Effect of Polymer Coating on Magnetic Nanocomposites’ Microwave Absorption(2016-02-27) UNVER, IBRAHIM SAIM; DURMUŞ, ZEHRA; KAVAS, H.; AKTAS, BEKIRPublication Metadata only Doğal İlaçlarla Sağlığı Korumak(2014-01-01) Kartal, MURAT; SEVGİ, ECE; KARTAL, MURAT; SEVGİ, ECEPublication Metadata only Antigenotoxic and antioxidant potentials of newly derivatized compound naringenin-oxime relative to naringenin on human mononuclear cells(2016-01-02) Kocyigit, ABDÜRRAHİM; Koyuncu, Ismail; Taskin, Abdullah; Dikilitas, Murat; Bahadori, FATEMEH; Turkkan, Baki; KOÇYİĞİT, ABDÜRRAHİM; BAHADORİ, FATEMEHWe investigated antigenotoxic and antioxidative effects of newly derivatized compound naringenin-oxime (NG-Ox) compared to its mother compound naringenin (NG) against oxidative damage induced by hydrogen peroxide (HP) in human peripheral blood mononuclear cells (PBMC). Antigenotoxic activity was assessed using alkaline single cell gel electrophoresis assay (comet assay). Oxidative status was evaluated by measurement of total antioxidant status, total oxidant status and lipid hydroperoxide levels in the cells. Oxidative stress index was also calculated. Both NG and NG-Ox show a protective effect against HP-induced oxidative damage on PBMC and are able to reduce oxidative stress. The percentage of antigenotoxic and antioxidant potential progressively increased in a dose-dependent manner. However, these activities were found to be more significant in NG-Ox-treated cells than in NG-treated cells. Taken together, these observations provide evidences indicating that both NG and NG-Ox are able to protect cells against oxidative damage and apparently NG-Ox is more effective than NG.Publication Metadata only Sülforafanın İnsan Böbrek Kanser Hücre Hattında Apoptotik Etkisi(2018-11-19) Atasoy, Sezen; Dağ, Aydan; Temel, BinnurPublication Metadata only Ursolik Asit ve Oleanolik Asitten Hareketle alfa-Amirin ve beta-Amirin Sentezi için Yeni ve Etkin Bir Yöntem(2017-04-29) SEÇEN, HASAN; ŞENOL, HALİL; TOPÇU, GÜLAÇTI; TUNCAY, SALİH; ÖCAL, NÜKET; ŞENOL, HALIL; TOPÇU, GÜLAÇTIPublication Metadata only Investigation of Bioactivities of Diterpenoids from some Teucrium Species Grown in Anatolia(2012-10-06) YILMAZ, ANIL; BOGA, MEHMET; TOPÇU, GÜLAÇTI; YILMAZ, ANIL; TOPÇU, GÜLAÇTIPublication Metadata only Opportunities and challenges in design and applications of nano drug delivery systems(2018-05-08) BAHADORİ, FATEMEH; BAHADORİ, FATEMEHPublication Metadata only Interactive effects of 9-cis-retinoic acid and androgen on proliferation, differentiation, and apoptosis of LNCaP prostate cancer cells.(2017-01-01) ESKRA, JN; KUIPER, JW; WALDEN, PD; BOSLAND, MC; Özten, NUR; ÖZTEN KANDAŞ, NURPublication Metadata only Synthesis of Biologically Active Novel Pyrrole Derivatives Containing Urea(2017-04-29) Özbilge, Ayşegül; ZENGİN KURT, BELMA; Sonmez, Fatih; ZENGİN KURT, BELMA