Search
Now showing items 1-10 of 67
Aromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies.
(2019-05-01)
A causal association is reported between prolonged exposures to elevated levels of estrogen and breast cancer. Therefore inhibiting aromatase (CYP19A), which catalyses the conversion of androgens to estrogens, is an important ...
Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.
(2019-12-01)
A large library of fibrate-based N-acylsulphonamides was designed, synthesised, and fully characterised in
order to propose them as zinc binders for the inhibition of human carbonic anhydrase (hCA) enzymatic
activity. ...
Preparation of single chain nanoparticles via photoinduced radical coupling process
(2019-04-01)
This contribution introduces a straightforward method for preparing well-defined polymeric nanoparticles using radical coupling process of ketyl moieties resulted from triplet excitation of pendant benzophenone groups. In ...
Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents
(2019-07-04)
Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. ...
Two New Co(II) Complexes of Picolinate: Synthesis, Crystal Structure, Spectral Characterization, -Glucosidase nhibition and TD/DFT Study
(2019-07-01)
Co(II) complexes of 2-picolinic acid (picH) and 6-methylpyridine-2-carboxylic acid (6-MepicH) {[Co(pic)(2)2H(2)O], (1), [Co(6-Mepic)(pic)2H(2)O], (2)} were obtained and their structural and spectroscopic properties were ...