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Development and validation of a HPLC method for the determination of benzo(a)pyrene in human breast milk
(2017-04-01)
A simple analytical procedure was developed for the quantitation of benzo(a)pyrene in human breast milk using solid phase extraction (SPE) combined with high performance liquid chromatography. Before the chromatographic ...
Anticholinesterase, antioxidant, antiaflatoxigenic activities of ten edible wild plants from Ordu area, Turkey
(2018-06-01)
Turkey has highly rich floras of medicinal and aromatic plants because of having various
climate conditions in different regions. One of these regions is Middle Black Sea Region,
especially Ordu Province. Extracts of 10 ...
Method Validation for the Quantitative Analysis of Aflatoxins (B1, B2, G1, and G2) and Ochratoxin A in Processed Cereal-Based Foods by HPLC with Fluorescence Detection
(2015-07-01)
Modified AOAC 991.31 and AOAC 2000.03 methods for the simultaneous determination of total aflatoxins (AFs), aflatoxin B1, and ochratoxin A (OTA) in processed cereal-based foods by RP-HPLC coupled with fluorescence detection ...
Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.
(2019-12-01)
A large library of fibrate-based N-acylsulphonamides was designed, synthesised, and fully characterised in
order to propose them as zinc binders for the inhibition of human carbonic anhydrase (hCA) enzymatic
activity. ...
Aromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies.
(2019-05-01)
A causal association is reported between prolonged exposures to elevated levels of estrogen and breast cancer. Therefore inhibiting aromatase (CYP19A), which catalyses the conversion of androgens to estrogens, is an important ...
Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation
(2017-11-01)
Self-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes of Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. All commercially ...
Flavonoid constituents of Sideritis caesarea
(2013-01-01)
The acetone extract of the aerial parts of Sideritis caesarea Duman, Aytac & Baser (Lamiaceae) afforded the flavonoids penduletin (1) and apigenin (2) and 6 glycosylated flavonoids, 4--O-methyl-isoscutellarein-7-O-[6 ...
SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors
(2019-04-01)
Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ...
Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer’s Disease
(2014-02-01)
Alzheimer’s disease (AD) is one of the most common and progressive neurodegenerative disorders with dementia in the world. The precise causes of AD are not fully understood yet, although several important features of its ...