Person: ÇELİK, BURAK
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Publication Open Access Design, optimization and characterization of coenzyme Q10-and D-panthenyl triacetate-loaded liposomes(2017-01-01) Celik, BURAK; Sagiroglu, ALİ; Ozdemir, Samet; ÇELİK, BURAK; ASRAM SAĞIROĞLU, ALİCoenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized by applying response surface methodology for increased stability and skin penetration. The optimum formulation comprised 4.17 mg CoQ10, 4.22 mg PTA and 13.95 mg cholesterol per 100 mg of soy phosphatidylcholine. The encapsulation efficiency of the optimized formulation for CoQ10 and PTA was found to be 90.89%±3.61% and 87.84%±4.61%, respectively. Narrow size distribution was achieved with an average size of 161.6±3.6 nm, while a spherical and uniform shape was confirmed via scanning electron microscopy and transmission electron microscopy images. Cumulative release of 90.93% for PTA and 24.41% for CoQ10 was achieved after 24 hours of in vitro release study in sink conditions. Physical stability tests indicated that the optimized liposomes were suitable for storage at 4°C for at least 60 days. The results suggest that the optimized liposomal formulation would be a promising delivery system for both ingredients in various topical applications. Keywords: coenzyme Q10, D-panthenyl triacetate, liposomes, response surface methodology, stabilityPublication Metadata only Hedeflendirilmiş Nanoilaçlar(2017-09-01) ÖNYÜKSEL, Hayat; BAHADORİ, FATEMEH; ÇELİK, BURAK; BAHADORİ, FATEMEH; ÇELİK, BURAKPublication Metadata only Therapeutic Potential of Drug Delivery by Means of Lipid Nanoparticles: Reality or Illusion?(2017-01-01) Uner, Melike; Damgali, Sukran; Ozdemir, Samet; Celik, BURAK; ÇELİK, BURAKBackground: Solid lipid nanoparticles (SLN) are colloidal drug carrier systems that contribute several properties required from a sophisticated drug delivery system for increasing drug bioavailability and providing effective therapy. Many advantages of SLN have been reported over traditional dosage forms and their colloidal counterparts since the early 1990s. They were optimized for oral drug delivery for the first time. The first SLN formulations were produced by reducing particle size of solid lipid microparticles by spray congealing technique in the late 1980s. Then, studies have been continued investigating for their different administration routes else including parenteral, transdermal, ocular, nasal, respiratory etc.Publication Open Access Risperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation(2017-11-01) ÇELİK, BURAK; ÇELİK, BURAKThe aim of this study was to design and optimize risperidone (RIS) mucoadhesive buccal tablets for systemic delivery as an alternative route. Direct compression method was used for the preparation of buccal tablets, and screening studies were conducted with different polymers to determine their effects on tablet characteristics. Carbopol® (CP) and sodium alginate (SA) were selected as two polymer types for further optimization studies by applying response surface methodology. Tablet hardness (TH), ex vivo residence time (RT), and peak detachment force (DF) from buccal mucosa were selected as three important responses. Physicochemical compatibility of formulation excipients and RIS was evaluated by using Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC) analysis. In vitro drug release profiles and release kinetics were investigated; swelling index and matrix erosion studies were conducted. Optimum formulation consisted of 16.4% CP and 20.3% SA, which provided 7.67±0.29 hour ex vivo RT, 45.52±4.85 N TH, and 2.12±0.17 N DF. FT-IR spectroscopy and DSC analysis revealed that there was no chemical interaction present between tablet ingredients. Cumulative RIS release of .90% was achieved after 8 hours of in vitro dissolution studies, which was supported by swelling and matrix erosion analysis. Mechanism of RIS release was fitted best to zero-order model, while release exponent (n) value of 0.77 demonstrated an anomalous (non-Fickian) release, indicating combined erosion and swelling mechanism. The results suggested that optimized buccal tablets of RIS would be a promising and alternative delivery system for the treatment of schizophrenia.Publication Metadata only Evaluation of Wound Healing Potential of New Composite Liposomal Films Containing Coenzyme Q10 and D-Panthenyl Triacetate as Combinational Treatment.(2021-02-13T00:00:00Z) Sağıroğlu, Ali Asram; Çelik, Burak; Güler, Eray Metin; Koçyiğit, ABDÜRRAHİM; Özer, Özgen; ASRAM SAĞIROĞLU, ALİ; ÇELİK, BURAK; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Targeted Nanomedicines for Cancer Therapy, From Basics to Clinical Trials(2020-04-30T00:00:00Z) Eskandari, Zahra; BAHADORİ, FATEMEH; ÇELİK, BURAK; Onyuksel, Hayat; BAHADORİ, FATEMEH; ÇELİK, BURAKTraditional systemic chemotherapy involves the wide distribution of drug molecules in the body, causing toxic side effects in the healthy tissues and limiting the therapeutic dose required at the site of drug action. In order to decrease side effects and increase the drug efficacy, recent research on chemotherapy focuses on drug targeting. Targeted therapy can be achieved by several mechanisms including; 1) using an antibody as a drug that is specific to a disease biomarker, 2) using an antibody (or peptide) as a targeting agent conjugated to the drug molecule, 3) delivering the drug molecules to the target tissue in a nano-carrier with or without the targeting agent attached on its surface. The third approach involves the nanomedicines that can be targeted to diseased tissues by both passive (extravasating at diseased sites due to leaky vasculature) and active (specific interaction of the targeting agent with disease biomarker) targeting mechanisms. In this review we will cover the passively targeted nanomedicines prepared using nano drug carriers. Ideally the carrier particle should be in the right size (1-100nm), stable enough to prevent drug leakage during circulation, and safe not to cause any damage to healthy tissues. Competition for all these properties generated many different types of materials to be used as nanodrug delivery systems. After a brief review of most commonly used drug carriers, we discuss the clinical use of the targeted nanomedicines with regard to their pharmacokinetic and pharmacodynamics properties, and how these properties vary from conventional formulations providing free drugs in the circulation after administration.Publication Metadata only Optimization of piribedil mucoadhesive tablets for efficient therapy of Parkinson-s disease: physical characterization and ex vivo drug permeation through buccal mucosa(2017-01-01) Celik, BURAK; Ozdemir, Samet; Demirkoz, Asli Barla; Uner, Melike; ÇELİK, BURAKObjective: The aim of this study was optimization of buccal piribedil (PR) mucoadhesive tablets to improve its low bioavailability and provide controlled release for the treatment of Parkinson-s disease.Publication Metadata only Eplerenone nanoemulsions for treatment of hypertension. Part II: Physical stability assessment and in vivo study(2018-06-01T00:00:00Z) Ozdemir, Samet; Celik, BURAK; Sumer, Engin; Acar, Ebru Turkoz; Uner, Melike; ÇELİK, BURAKThe aim of the present complimentary study was to investigate physical stability of eplerenone (EP) loaded nanoemulsions and to evaluate their pharmacokinetic profiles after subcutaneous application to Sprague Dawley rats. Nanoemulsions were prepared by using high shear homogenization and ultrasonication techniques. All formulations were having 0.1% EP. They were obtained in 150.6 nm-205.8 nm size range. Physical stability of nanoemulsions was monitored storing them at different thermal conditions for 120 days. Droplet size was confirmed to be affected by storage temperature when it slightly changed at 4 +/- 2 degrees C and 25 +/- 2 degrees C. 40 +/- 2 degrees C was found not to be suitable as a storage condition in general. Pharmacokinetic study on physically stable formulations demonstrated that subcutaneously applied eplerenone solution showed that AUC(0)->infinity and C-max were 1.62 and 2.05 folds higher than eplerenone solution after oral administration. Additionally, AUC(0)->infinity and C-max were significantly increased in the case of nanoemulsions prepared with Brij (R) 35 and Tween (R) 80. Relative bioavailability of the drug was found to be remarkably increased after administration of formulations stabilized with Tween (R) 80. Results suggested that eplerenone loaded nanoemulsions may provide an alternative application way for efficient management of hypertension attacks.Publication Metadata only INFLUENCE OF VEHICLES AND PENETRATION ENHANCERS ON ANTI-INFLAMMATORY EFFECT OF 18-beta GLYCYRRHETINIC ACID: KINETIC MODELLING OF DRUG RELEASE, IN VIVO AND EX VIVO EXPERIMENTS(2020-07-01T00:00:00Z) Karaman, Ecem Fatma; ÇELİK, BURAK; Ozdemir, Samet; Tekkeli, Evrim Kepekci; Demirkoz, Asli Barla; Gonullu, Umit; Uner, Melike; ÇELİK, BURAK; TEKKELİ, ŞERİFE EVRİMTopical formulations of 18-beta glycyrrhetinic acid (18-beta GA) were designed for use in relieving inflammatory and painful conditions of the skin. Formulations were containing penetration enhancers that differ in penetration enhancing mechanisms. Anti-inflammatory effects of formulations and effects of penetration enhancers on penetration and permeation of the drug through rat skin were investigated. The total amount of 18-beta GA permeated from the base oil/water emulsion (53.19 +/- 22.25 mcg/cm(2) ) was approximately twice higher than the base oleaginous cream (29.17 +/- 3.85 mcg/cm(2)) while there was no 18-beta GA permeation from the base hydrogel formulation to the skin (p < 0.05). Incorporation of propylene glycol was generally found to increase 18-beta GA permeation to the skin. The highest oedema inhibiting activity was achieved in the oil/water emulsion containing propylene glycol followed by the base oil/water emulsion without a penetration enhancer (p < 0.05). This result was consistent with the ex vivo study. Limonene and oleic acid were found to be insufficient in 18-beta GA permeation to the skin.Publication Metadata only Intraocular pressure in infants and its association with hormonal changes with vaginal birth versus cesarean section.(2016-12-01) Elbay, AHMET; CELIK, U; CELIK, BURAK; OZER, OF; KILIC, GÖKHAN; AKKAN, JC; BAYRAKTAR, BİLGE; KAYMAK, NZ; ELBAY, AHMET; ÇELİK, BURAK; ÖZER, ÖMER FARUK; KILIC, GÖKHAN; BAYRAKTAR, BILGE