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Now showing 1 - 6 of 6
  • PublicationOpen Access
    Comparison of the biochemical and radiological criteria for lumbar disc degeneration
    (2018-09-01) Seyithanoglu, MEHMET HAKAN; Kitis, SERKAN; Ozer, Omer Faruk; Kocyigit, ABDÜRRAHİM; DÜNDAR, Tolga; Papaker, Meliha Gundeg; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM
    Background: The relationship between radiological degeneration criteria on lumbar magnetic resonance imaging (MRI) and both the keratan sulfate (KS) and chondroitin sulfate (ChS) levels was examined in disc material taken from patients undergoing lumbar disc herniation (LDH) surgery. To examine whether the biochemical and radiological degeneration criteria testing the reliability of radiological degeneration findings agreed and to evaluate the contribution of the KS/ChS ratio to disc form (protruding or extruding).
  • PublicationOpen Access
    An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats
    Objectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.
  • PublicationOpen Access
    Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor
    (2016-10-13) Kılıç, Elif; Ozer, Omer Faruk; Erek, Aybala Toprak; ERMAN, HAYRİYE; Torun, EMEL; AYHAN, Siddika Kesgin; Caglar, HİFA GÜLRU; Selek, Sahbettin; Kocyigit, ABDÜRRAHİM; ÖZER, ÖMER FARUK; TORUN, EMEL; ÇAĞLAR, HİFA GÜLRU; SELEK, ŞAHABETTİN; KOÇYİĞİT, ABDÜRRAHİM
    Background: Childhood obesity characterized by excessive fat in the body is one of the most serious health problems worldwide due to the social, medical, and physiological complications. Obesity and associated diseases are triggering factors for oxidative stress and inflammation. The aim of this study was to explore the possible association between childhood obesity and inflammatory and oxidative status. Material/Methods: Thirty-seven obese children and 37 healthy controls selected from among children admitted to BLIND University Paediatrics Department were included in the study. Anthropometric measurements were performed using standard methods. Glucose, lipid parameters, CRP, insulin, total oxidant status (TOS), total anti-oxidant status (TAS) levels, and total thiol levels (TTL) were measured in serum. HOMA index (HOMA-IR) were calculated. The differences between the groups were evaluated statistically using the Mann-Whitney U test. Results: Body mass index was significantly higher in the obese group (median: 28.31(p<0.001). Glucose metabolism, insulin, and HOMA-IR levels were significantly higher in the obese group (both p<0.001). Total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride levels were significantly higher in the obese group (p<0.001). TAS (med: 2.5 µmol Trolox eq/L (1.7–3.3)) and TOS (med: 49.1 µmol H2 O2 eq/L (34.5–78.8)) levels and TTL (med: 0.22 mmol/L (0.16–0.26)) were significantly higher in the obese group (p=0.001). CRP levels showed positive correlation with TOS and negative correlation with TTL levels (p=0.005, r=0.473; p=0.01, r=–0.417; respectively). TTL levels exhibited negative correlation with TOS levels (p=0.03, r=–0.347). Conclusions: In conclusion, obese children were exposed to more oxidative burden than children with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. Widely focussed studies are required on the use of oxidative parameters as early prognostic parameters in detection of obesity-related complications
  • PublicationOpen Access
    Reduced antioxidant capacity and increased subclinical inflammation markers in prepubescent obese children and their relationship with nutritional markers and metabolic parameters
    (2016-01-01T00:00:00Z) Vehapoglu, AYSEL; TURKMEN, Serdar; GOKNAR, Nilufer; Ozer, Omer Faruk; VEHAPOĞLU TÜRKMEN, AYSEL; ÖZER, ÖMER FARUK
    Objective: There are associations between some inflammatory and oxidative markers and obesity in adults, but whether prepubescent children of different weights also have such markers has not been studied. We investigated multiple inflammatory markers and levels of erythrocyte oxidant/antioxidant enzymes in prepubescent children of different weights.
  • PublicationOpen Access
    Oxidative/antioxidative status, lymphocyte DNA damage, and urotensin-2 receptor level in patients with migraine attacks
    Background: The present study investigated the potential roles of plasma lymphocyte DNA damage, the urotensin-2 receptor (UTS2R), and oxidative changes in patients with varying degrees of migraine-related disability who were in the ictal phase and presented to our emergency department. Methods: This study enrolled 40 consecutive adult patients with migraine attack and 40 age- and sex-matched healthy controls. The same health care professional determined the headache-related disability of each patient’s migraine attack using the Migraine Disability Assessment Scale (MIDAS); patients were divided into three groups based on MIDAS score. Plasma lymphocyte DNA damage; UTS2R, malondialdehyde (MDA), and catalase (CAT) levels; total oxidant status (TOS); total antioxidant status (TAS); and the oxidative stress index (OSI) were used as predictors of early oxidative changes. Results: Plasma lymphocyte DNA damage, TOS, MDA levels, and OSI values were significantly higher in patients with migraine compared to controls. Conversely, TAS and CAT and UTS2R levels were markedly lower in patients with migraine compared to controls. Comparisons of the patient groups by MIDAS score revealed significant differences in plasma lymphocyte DNA damage and CAT levels but no differences in TOS, MDA levels, OSI, TAS, or UTS2R levels. MIDAS scores were positively correlated with the degree of lymphocyte DNA damage, but neither of these factors was significantly related to CAT levels. Conclusion: The present data suggest that lymphocyte DNA damage and changes in oxidative/ antioxidative status may reflect an enhanced oxidative damage and an ineffective antioxidant defense system in migraineurs during headache attacks. In addition, lymphocyte DNA damage levels may be an indicator of the degree of migraine-related disability as assessed by MIDAS score.
  • PublicationOpen Access
    Protective Effects of Silymarin against Cardiac Tissue Injury Caused By a High-dose Administration of Isotretinoin in Mice
    (2016-08-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Ozer, Omer Faruk; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; ÖZER, ÖMER FARUK
    Objective: We aimed to histopathologically and biochemically investigate the protective effects of silymarin (SLY) against cardiac injury induced by a high-dose isotretinoin (ISR) administration. Methods: Thirty-two male Balb/c mice were divided into four groups: control, ISR, SLY, and co-treated (ISR+SLY) groups. For the histopathological analysis, all sections were stained with hematoxylin eosin and Masson's trichrome. The TUNEL detection kit was used for the detection of cardiac apoptosis. The oxidative stress markers, which included catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px), and glutathione reductase (GSH-red), and the glutathione S-transferase (GST) and lipid peroxidation markers, which included erythrocyte malondialdehyde (E-MDA) and plasma malondialdehyde (P-MDA), were biochemically determined. All statistical analyses were conducted with SPSS 18.0 (IBM, New York, USA) and GraphPad Prism Version 6.01 (USA). The Student's t-test was applied to the parametric data for comprising among groups. The P-significance degree was evaluated as 95%. Results: Severe histopathological alterations were observed in cardiac tissue. The ISR group showed hemorrhage, necrosis, edema, and congestion in cardiac tissues. SLY did not improve ISR-induced histopathological changes (p>0.05). The highest number of apoptotic cells was detected in the ISR group. In the ISR+SLY group, SLY treatment reduced apoptosis (p <= 0.05). Antioxidant enzyme activities (CAT, SOD, GSH-Px, GSH-Red, GSH, GST) were induced in ISR+SLY group (p=0.015, p>0.05, p=0.002, p=0.002, p=0,018, p=0.002; respectively). E-MDA (p=0.003) and P-MDA (p=0.005) levels significantly increased in the ISR group and decreased in the SLY group. Conclusion: SLY increased antioxidant enzyme activities, prevented lipid peroxidation, and decreased apoptosis. SLY was found to be an antioxidant against ISR-induced cardiac oxidative damage.